Missense Suppressor TRNA Therapeutics Correct Disease-causing Alleles by Misreading the Genetic Code

Overview

Journal Mol Ther

Publisher Cell Press

Specialties Molecular Biology
Pharmacology

Date 2024 Jan 14

PMID 38219738

Authors

Teija M I Bily

Ilka U Heinemann

Patrick ODonoghue

Affiliations

Soon will be listed here.

Citing Articles

Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation.

Tennakoon R, Bily T, Hasan F, Syal S, Voigt A, Balci T Mol Ther Nucleic Acids. 2025; 36(1):102442.

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Tuning tRNAs for improved translation.

Weiss J, Decker J, Bolano A, Krahn N Front Genet. 2024; 15:1436860.

PMID: 38983271 PMC: 11231383. DOI: 10.3389/fgene.2024.1436860.

Mechanisms and Delivery of tRNA Therapeutics.

Ward C, Beharry A, Tennakoon R, Rozik P, Wilhelm S, Heinemann I Chem Rev. 2024; 124(12):7976-8008.

PMID: 38801719 PMC: 11212642. DOI: 10.1021/acs.chemrev.4c00142.

Mistranslating the genetic code with leucine in yeast and mammalian cells.

Davey-Young J, Hasan F, Tennakoon R, Rozik P, Moore H, Hall P RNA Biol. 2024; 21(1):1-23.

PMID: 38629491 PMC: 11028032. DOI: 10.1080/15476286.2024.2340297.

References

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Lant J, Berg M, Heinemann I, Brandl C, ODonoghue P . Pathways to disease from natural variations in human cytoplasmic tRNAs. J Biol Chem. 2019; 294(14):5294-5308. PMC: 6462537. DOI: 10.1074/jbc.REV118.002982. View

Hasan F, Lant J, ODonoghue P . Perseverance of protein homeostasis despite mistranslation of glycine codons with alanine. Philos Trans R Soc Lond B Biol Sci. 2023; 378(1871):20220029. PMC: 9835607. DOI: 10.1098/rstb.2022.0029. View

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