Extracellular Vesicles in Atherosclerosis: State of the Art

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Jan 11

PMID 38203558

Authors

Wioletta Olejarz

Karol Sadowski

Klaudia Radoszkiewicz

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in the arteries, leading to narrowing and thrombosis that causes mortality. Emerging evidence has confirmed that atherosclerosis affects younger people and is involved in the majority of deaths worldwide. EVs are associated with critical steps in atherosclerosis, cholesterol metabolism, immune response, endothelial dysfunction, vascular inflammation, and remodeling. Endothelial cell-derived EVs can interact with platelets and monocytes, thereby influencing endothelial dysfunction, atherosclerotic plaque destabilization, and the formation of thrombus. EVs are potential diagnostic and prognostic biomarkers in atherosclerosis (AS) and cardiovascular disease (CVD). Importantly, EVs derived from stem/progenitor cells are essential mediators of cardiogenesis and cardioprotection and may be used in regenerative medicine and tissue engineering.

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References

Pan Y, Liu Y, Wei W, Yang X, Wang Z, Xin W . Extracellular Vesicles as Delivery Shippers for Noncoding RNA-Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer. Small. 2023; 19(17):e2205739. DOI: 10.1002/smll.202205739. View

Singh S, de Ronde M, Kok M, Beijk M, de Winter R, van der Wal A . MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability. Open Heart. 2020; 7(1). PMC: 7269547. DOI: 10.1136/openhrt-2019-001223. View

Xiao J, Pan Y, Li X, Yang X, Feng Y, Tan H . Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4. Cell Death Dis. 2016; 7(6):e2277. PMC: 5143405. DOI: 10.1038/cddis.2016.181. View

Jansen F, Yang X, Franklin B, Hoelscher M, Schmitz T, Bedorf J . High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation. Cardiovasc Res. 2013; 98(1):94-106. DOI: 10.1093/cvr/cvt013. View

Lu Y, Thavarajah T, Gu W, Cai J, Xu Q . Impact of miRNA in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2018; 38(9):e159-e170. PMC: 6795547. DOI: 10.1161/ATVBAHA.118.310227. View

Wang X, Wang R, Jiang L, Xu Q, Guo X . Endothelial repair by stem and progenitor cells. J Mol Cell Cardiol. 2021; 163:133-146. DOI: 10.1016/j.yjmcc.2021.10.009. View

Bearzi C, Rota M, Hosoda T, Tillmanns J, Nascimbene A, De Angelis A . Human cardiac stem cells. Proc Natl Acad Sci U S A. 2007; 104(35):14068-73. PMC: 1955818. DOI: 10.1073/pnas.0706760104. View

Suades R, Padro T, Alonso R, Mata P, Badimon L . High levels of TSP1+/CD142+ platelet-derived microparticles characterise young patients with high cardiovascular risk and subclinical atherosclerosis. Thromb Haemost. 2015; 114(6):1310-21. DOI: 10.1160/TH15-04-0325. View

Zhuang Y, Cheng M, Li M, Cui J, Huang J, Zhang C . Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway. Acta Biomater. 2022; 150:413-426. DOI: 10.1016/j.actbio.2022.07.015. View

10.

Brodsky S, Zhang F, Nasjletti A, Goligorsky M . Endothelium-derived microparticles impair endothelial function in vitro. Am J Physiol Heart Circ Physiol. 2004; 286(5):H1910-5. DOI: 10.1152/ajpheart.01172.2003. View

11.

Lu M, Yuan S, Li S, Li L, Liu M, Wan S . The Exosome-Derived Biomarker in Atherosclerosis and Its Clinical Application. J Cardiovasc Transl Res. 2018; 12(1):68-74. DOI: 10.1007/s12265-018-9796-y. View

12.

Ghassemi K, Inouye K, Takhmazyan T, Bonavida V, Yang J, de Barros N . Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration. Gels. 2023; 9(10). PMC: 10606880. DOI: 10.3390/gels9100824. View

13.

Chironi G, Simon A, Hugel B, Del Pino M, Gariepy J, Freyssinet J . Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects. Arterioscler Thromb Vasc Biol. 2006; 26(12):2775-80. DOI: 10.1161/01.ATV.0000249639.36915.04. View

14.

Lee S, Chu K, Jung K, Kim J, Moon H, Bahn J . Circulating CD62E+ microparticles and cardiovascular outcomes. PLoS One. 2012; 7(4):e35713. PMC: 3338519. DOI: 10.1371/journal.pone.0035713. View

15.

Amabile N, Rautou P, Tedgui A, Boulanger C . Microparticles: key protagonists in cardiovascular disorders. Semin Thromb Hemost. 2010; 36(8):907-16. DOI: 10.1055/s-0030-1267044. View

16.

Sansone R, Baaken M, Horn P, Schuler D, Westenfeld R, Amabile N . Endothelial microparticles and vascular parameters in subjects with and without arterial hypertension and coronary artery disease. Data Brief. 2018; 19:495-500. PMC: 5997624. DOI: 10.1016/j.dib.2018.04.149. View

17.

Spacek M, Zemanek D, Hutyra M, Sluka M, Taborsky M . Vulnerable atherosclerotic plaque - a review of current concepts and advanced imaging. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018; 162(1):10-17. DOI: 10.5507/bp.2018.004. View

18.

Bernal-Mizrachi L, Jy W, Jimenez J, Pastor J, Mauro L, Horstman L . High levels of circulating endothelial microparticles in patients with acute coronary syndromes. Am Heart J. 2003; 145(6):962-70. DOI: 10.1016/S0002-8703(03)00103-0. View

19.

Xing Z, Zhao C, Liu H, Fan Y . Endothelial Progenitor Cell-Derived Extracellular Vesicles: A Novel Candidate for Regenerative Medicine and Disease Treatment. Adv Healthc Mater. 2020; 9(12):e2000255. DOI: 10.1002/adhm.202000255. View

20.

Chen X, Huang F, Liu Y, Liu S, Tan G . Exosomal miR-152-5p and miR-3681-5p function as potential biomarkers for ST-segment elevation myocardial infarction. Clinics (Sao Paulo). 2022; 77:100038. PMC: 9243048. DOI: 10.1016/j.clinsp.2022.100038. View