The Exosome-Derived Biomarker in Atherosclerosis and Its Clinical Application

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2018 May 27

PMID 29802541

Citations 64

Authors

Mengmeng Lu

Shuaifang Yuan

Shicheng Li

Ling Li

Min Liu

Shaogui Wan

Affiliations

Soon will be listed here.

Abstract

Exosomes are now accepted as potential biomarkers in cardiovascular disease development, especially in atherosclerosis. Atherosclerosis is a leading cause of cardiovascular disease-related death and morbidity, accounting for one-fifth of all deaths globally. Therefore, the biomarkers for the management of atherosclerosis is urgently needed. Exosomes are reported to play key roles cell-to-cell communication in atherosclerosis with lipid bilayer membranous vesicles containing nucleic acids, proteins, and lipid contents, which are released from all most of multiple kinds of living cells. This review aims to discuss the potential roles of exosome-derived miRNA, protein, and DNA as biomarkers in atherosclerosis pathogenesis, diagnosis, and therapy.

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