Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration

Overview

Journal Gels

Date 2023 Oct 27

PMID 37888397

Authors

Kaitlyn Ghassemi

Keiko Inouye

Tatevik Takhmazyan

Victor Bonavida

Jia-Wei Yang

Natan Roberto de Barros

Finosh G Thankam

Affiliations

Soon will be listed here.

Abstract

Increased prevalence of cardiovascular disease and potentially life-threatening complications of myocardial infarction (MI) has led to emerging therapeutic approaches focusing on myocardial regeneration and restoration of physiologic function following infarction. Extracellular vesicle (EV) technology has gained attention owing to the biological potential to modulate cellular immune responses and promote the repair of damaged tissue. Also, EVs are involved in local and distant cellular communication following damage and play an important role in initiating the repair process. Vesicles derived from stem cells and cardiomyocytes (CM) are of particular interest due to their ability to promote cell growth, proliferation, and angiogenesis following MI. Although a promising candidate for myocardial repair, EV technology is limited by the short retention time of vesicles and rapid elimination by the body. There have been several successful attempts to address this shortcoming, which includes hydrogel technology for the sustained bioavailability of EVs. This review discusses and summarizes current understanding regarding EV technology in the context of myocardial repair.

Citing Articles

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