Nutraceutical Properties of Syringic Acid in Civilization Diseases-Review

Overview

Journal Nutrients

Date 2024 Jan 11

PMID 38201840

Authors

Iga Bartel

Izabela Mandryk

Jaroslaw O Horbanczuk

Agnieszka Wierzbicka

Magdalena Koszarska

Affiliations

Soon will be listed here.

Abstract

Civilization diseases account for a worldwide health issue. They result from daily behavioral, environmental, and genetic factors. One of the most significant opportunities to prevent and alleviate the occurrence of these diseases is a diet rich in antioxidants like polyphenols. This review paper is concentrated on syringic acid (SA), one of the representative compounds of phenolic acids subgroups. There are many in vitro and in vivo studies on SA that assess its pivotal effects on oxidative stress and inflammation parameters. It is effective on metabolic risk factors as well, including hyperglycemia, high blood pressure, and hyperlipidemia. SA is one of the prominent polyphenolic compounds that may help address health issues related to civilization diseases.

Citing Articles

Phytochemical Composition and Antioxidant Activity of Manuka Honey and Ohia Lehua Honey.

Morar I, Pop R, Peitzner E, Ranga F, Orasan M, Cecan A Nutrients. 2025; 17(2).

PMID: 39861404 PMC: 11767333. DOI: 10.3390/nu17020276.

Role of syringic acid in enhancing growth, photosynthesis, and antioxidant defense in lettuce exposed to arsenic stress.

Balci M, Arikan-Abdulveli B, Yildiztugay E, Ozfidan-Konakci C Physiol Plant. 2025; 177(1):e70051.

PMID: 39812165 PMC: 11744429. DOI: 10.1111/ppl.70051.

Rapid Assessment of Metabolomic Fingerprinting of Recycled Sunflower By-Products via DART-HRMS.

Zacometti C, Lante A, Cisneros M, Massaro A, Mihaylova D, Chalova V Molecules. 2024; 29(17).

PMID: 39274940 PMC: 11397051. DOI: 10.3390/molecules29174092.

The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects.

Alves L, Moore J, Kell D Int J Mol Sci. 2024; 25(16).

PMID: 39201768 PMC: 11354673. DOI: 10.3390/ijms25169082.

Biological Properties, Health Benefits and Semisynthetic Derivatives of Edible Astraeus Mushrooms (Diplocystidiaceae): A Comprehensive Review.

Ung A, Chen H Chem Biodivers. 2024; 21(12):e202401295.

PMID: 39177069 PMC: 11644123. DOI: 10.1002/cbdv.202401295.

References

Ogut E, Armagan K, Gul Z . The role of syringic acid as a neuroprotective agent for neurodegenerative disorders and future expectations. Metab Brain Dis. 2022; 37(4):859-880. DOI: 10.1007/s11011-022-00960-3. View

Al-Farsi M, Alasalvar C, Morris A, Baron M, Shahidi F . Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. J Agric Food Chem. 2005; 53(19):7592-9. DOI: 10.1021/jf050579q. View

Tokmak M, Yuksel Y, Sehitoglu M, Guven M, Akman T, Aras A . The Neuroprotective Effect of Syringic Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats. Inflammation. 2015; 38(5):1969-78. DOI: 10.1007/s10753-015-0177-2. View

Han X, Bai L, Kee H, Jeong M . Syringic acid mitigates isoproterenol-induced cardiac hypertrophy and fibrosis by downregulating Ereg. J Cell Mol Med. 2022; 26(14):4076-4086. PMC: 9279583. DOI: 10.1111/jcmm.17449. View

Lee M, Kang H, Lee K, Yang G, Ham I, Bu Y . The aerial part of Taraxacum coreanum extract has an anti-inflammatory effect on peritoneal macrophages in vitro and increases survival in a mouse model of septic shock. J Ethnopharmacol. 2012; 146(1):1-8. DOI: 10.1016/j.jep.2012.12.009. View

Wei X, Chen D, Yi Y, Qi H, Gao X, Fang H . Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. Evid Based Complement Alternat Med. 2013; 2012:426537. PMC: 3545393. DOI: 10.1155/2012/426537. View

Mishra V, Jana A, Jana M, Gupta A . Improvement of selective lignin degradation in fungal pretreatment of sweet sorghum bagasse using synergistic CuSO-syringic acid supplements. J Environ Manage. 2017; 193:558-566. DOI: 10.1016/j.jenvman.2017.02.057. View

Nascimento-Souza M, Paiva P, Perez-Jimenez J, Franceschini S, Ribeiro A . Estimated dietary intake and major food sources of polyphenols in elderly of Viçosa, Brazil: a population-based study. Eur J Nutr. 2016; 57(2):617-627. DOI: 10.1007/s00394-016-1348-0. View

Yu J, Zhu Y, Wang L, Peng M, Tong S, Cao X . Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles. Acta Pharmacol Sin. 2010; 31(6):759-64. PMC: 4002977. DOI: 10.1038/aps.2010.55. View

10.

Yeung A, Tzvetkov N, Durazzo A, Lucarini M, Souto E, Santini A . Natural products in diabetes research: quantitative literature analysis. Nat Prod Res. 2020; 35(24):5813-5827. DOI: 10.1080/14786419.2020.1821019. View

11.

Kumar S, Prahalathan P, Raja B . Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 2012; 385(12):1175-84. DOI: 10.1007/s00210-012-0802-7. View

12.

Jalili T, Carlstrom J, Kim S, Freeman D, Jin H, Wu T . Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction. J Cardiovasc Pharmacol. 2006; 47(4):531-41. DOI: 10.1097/01.fjc.0000211746.78454.50. View

13.

Mittelstadt G, Negron L, Schofield L, Marsh K, Parker E . Biochemical and structural characterisation of dehydroquinate synthase from the New Zealand kiwifruit Actinidia chinensis. Arch Biochem Biophys. 2013; 537(2):185-91. DOI: 10.1016/j.abb.2013.07.022. View

14.

Ferah Okkay I, Okkay U, Lutfi Gundogdu O, Bayram C, Mendil A, Sait Ertugrul M . Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence. Neurosci Lett. 2021; 769:136385. DOI: 10.1016/j.neulet.2021.136385. View

15.

Rohm T, Meier D, Olefsky J, Donath M . Inflammation in obesity, diabetes, and related disorders. Immunity. 2022; 55(1):31-55. PMC: 8773457. DOI: 10.1016/j.immuni.2021.12.013. View

16.

Younossi Z . Non-alcoholic fatty liver disease - A global public health perspective. J Hepatol. 2018; 70(3):531-544. DOI: 10.1016/j.jhep.2018.10.033. View

17.

Li Y, Zhang L, Wang X, Wu W, Qin R . Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma. Drug Dev Res. 2018; 80(2):253-261. DOI: 10.1002/ddr.21487. View

18.

Jantan I, Haque M, Arshad L, Harikrishnan H, Septama A, Mohamed-Hussein Z . Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways. J Nutr Biochem. 2021; 93:108634. DOI: 10.1016/j.jnutbio.2021.108634. View

19.

Cikman O, Soylemez O, Ozkan O, Kiraz H, Sayar I, Ademoglu S . Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in l-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats. Int Surg. 2015; 100(5):891-6. PMC: 4452979. DOI: 10.9738/INTSURG-D-14-00170.1. View

20.

Chen W, Zheng R, Zhang S, Zeng H, Zuo T, Xia C . Cancer incidence and mortality in China in 2013: an analysis based on urbanization level. Chin J Cancer Res. 2017; 29(1):1-10. PMC: 5348470. DOI: 10.21147/j.issn.1000-9604.2017.01.01. View