Biological Properties, Health Benefits and Semisynthetic Derivatives of Edible Astraeus Mushrooms (Diplocystidiaceae): A Comprehensive Review

Overview

Journal Chem Biodivers

Specialty Biochemistry

Date 2024 Aug 23

PMID 39177069

Authors

Alison T Ung

Hui Chen

Affiliations

Soon will be listed here.

Abstract

Edible Astraeus mushrooms are known for their nutritional and culinary benefits and potential therapeutic properties. However, more investigation and discussion are still needed to understand their mechanisms of action regarding observed biological activities and thorough chemical analysis of bioactive compounds. This review provides a comprehensive summary and discussion of the bioactive properties and mode of action of Astraeus extracts and their isolated compounds. It covers their reported antioxidant, anti-inflammatory, antidiabetic, anticancer, anti-tuberculosis, antimalarial, antiviral and antileishmanial activities, as well as their potential benefits on metabolic and cardiovascular health and immune function. The review highlights the significance of the biological potential of isolated compounds, such as sugar alcohols, polysaccharides, steroids, and lanostane triterpenoids. Moreover, the review identifies under-researched areas, such as the chemical analysis of Astraeus species, which holds immense research potential. Ultimately, the review aims to inspire further research on the nutraceuticals or therapeutics of these mushrooms.

Citing Articles

Biological Properties, Health Benefits and Semisynthetic Derivatives of Edible Astraeus Mushrooms (Diplocystidiaceae): A Comprehensive Review.

Ung A, Chen H Chem Biodivers. 2024; 21(12):e202401295.

PMID: 39177069 PMC: 11644123. DOI: 10.1002/cbdv.202401295.

References

Maccarrone M, Brune B . Redox regulation in acute and chronic inflammation. Cell Death Differ. 2009; 16(8):1184-6. DOI: 10.1038/cdd.2009.65. View

Cerletti C, Esposito S, Iacoviello L . Edible Mushrooms and Beta-Glucans: Impact on Human Health. Nutrients. 2021; 13(7). PMC: 8308413. DOI: 10.3390/nu13072195. View

Fuhrman B, Volkova N, Coleman R, Aviram M . Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity. J Nutr. 2005; 135(4):722-8. DOI: 10.1093/jn/135.4.722. View

Xiong M, Huang Y, Liu Y, Huang M, Song G, Ming Q . Antidiabetic Activity of Ergosterol from Pleurotus Ostreatus in KK-A Mice with Spontaneous Type 2 Diabetes Mellitus. Mol Nutr Food Res. 2017; 62(3). DOI: 10.1002/mnfr.201700444. View

El Enshasy H, Hatti-Kaul R . Mushroom immunomodulators: unique molecules with unlimited applications. Trends Biotechnol. 2013; 31(12):668-77. DOI: 10.1016/j.tibtech.2013.09.003. View

Mallick S, Maiti S, Bhutia S, Maiti T . Antitumor properties of a heteroglucan isolated from Astraeus hygrometricus on Dalton's lymphoma bearing mouse. Food Chem Toxicol. 2010; 48(8-9):2115-21. DOI: 10.1016/j.fct.2010.05.013. View

Livesey G . Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev. 2008; 16(2):163-91. DOI: 10.1079/NRR200371. View

Chukwuma C, Mopuri R, Nagiah S, Chuturgoon A, Islam M . Erythritol reduces small intestinal glucose absorption, increases muscle glucose uptake, improves glucose metabolic enzymes activities and increases expression of Glut-4 and IRS-1 in type 2 diabetic rats. Eur J Nutr. 2017; 57(7):2431-2444. DOI: 10.1007/s00394-017-1516-x. View

Chakraborty I, Mondal S, Rout D, Chandra K, Islam S . Structural investigation of a heteroglycan isolated from the fruit bodies of an ectomycorrhizal fungus Astraeus hygrometricus. Carbohydr Res. 2007; 342(7):982-7. DOI: 10.1016/j.carres.2007.02.004. View

10.

Omoruyi F, Stennett D, Foster S, Dilworth L . New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review. Molecules. 2020; 25(7). PMC: 7212753. DOI: 10.3390/molecules25071720. View

11.

Zeb M, Lee C . Medicinal Properties and Bioactive Compounds from Wild Mushrooms Native to North America. Molecules. 2021; 26(2). PMC: 7825331. DOI: 10.3390/molecules26020251. View

12.

Nandi S, Chandra S, Sikder R, Bhattacharya S, Ahir M, Biswal D . Characterization and Inception of a Triterpenoid Astrakurkurol, as a Cytotoxic Molecule on Human Hepatocellular Carcinoma Cells, Hep3B. J Agric Food Chem. 2019; 67(27):7660-7673. DOI: 10.1021/acs.jafc.9b01203. View

13.

Song S, Vieille C . Recent advances in the biological production of mannitol. Appl Microbiol Biotechnol. 2009; 84(1):55-62. DOI: 10.1007/s00253-009-2086-5. View

14.

Alegbe E, Terali K, Olofinsan K, Surgun S, Ogbaga C, Ajiboye T . Antidiabetic activity-guided isolation of gallic and protocatechuic acids from Hibiscus sabdariffa calyxes. J Food Biochem. 2019; 43(7):e12927. DOI: 10.1111/jfbc.12927. View

15.

Arpha K, Phosri C, Suwannasai N, Mongkolthanaruk W, Sodngam S . Astraodoric acids A-D: new lanostane triterpenes from edible mushroom Astraeus odoratus and their anti-Mycobacterium tuberculosis H37Ra and cytotoxic activity. J Agric Food Chem. 2012; 60(39):9834-41. DOI: 10.1021/jf302433r. View

16.

Wolnerhanssen B, Meyer-Gerspach A, Beglinger C, Islam M . Metabolic effects of the natural sweeteners xylitol and erythritol: A comprehensive review. Crit Rev Food Sci Nutr. 2019; 60(12):1986-1998. DOI: 10.1080/10408398.2019.1623757. View

17.

Zhang S, Gai Z, Gui T, Chen J, Chen Q, Li Y . Antioxidant Effects of Protocatechuic Acid and Protocatechuic Aldehyde: Old Wine in a New Bottle. Evid Based Complement Alternat Med. 2021; 2021:6139308. PMC: 8592717. DOI: 10.1155/2021/6139308. View

18.

Sillapachaiyaporn C, Nilkhet S, Ung A, Chuchawankul S . Anti-HIV-1 protease activity of the crude extracts and isolated compounds from Auricularia polytricha. BMC Complement Altern Med. 2019; 19(1):351. PMC: 6896332. DOI: 10.1186/s12906-019-2766-3. View

19.

Abitbol A, Mallard B, Tiralongo E, Tiralongo J . Mushroom Natural Products in Neurodegenerative Disease Drug Discovery. Cells. 2022; 11(23). PMC: 9740391. DOI: 10.3390/cells11233938. View

20.

Karami H, Shariatifar N, Nazmara S, Moazzen M, Mahmoodi B, Khaneghah A . The Concentration and Probabilistic Health Risk of Potentially Toxic Elements (PTEs) in Edible Mushrooms (Wild and Cultivated) Samples Collected from Different Cities of Iran. Biol Trace Elem Res. 2020; 199(1):389-400. DOI: 10.1007/s12011-020-02130-x. View