In Vitro Models for Investigating Intestinal Host-Pathogen Interactions

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2023 Dec 28

PMID 38155358

Authors

Reece McCoy

Sophie Oldroyd

Woojin Yang

Kaixin Wang

Darius Hoven

David Bulmer

Matthias Zilbauer

Roisin M Owens

Affiliations

Soon will be listed here.

Abstract

Infectious diseases are increasingly recognized as a major threat worldwide due to the rise of antimicrobial resistance and the emergence of novel pathogens. In vitro models that can adequately mimic in vivo gastrointestinal physiology are in high demand to elucidate mechanisms behind pathogen infectivity, and to aid the design of effective preventive and therapeutic interventions. There exists a trade-off between simple and high throughput models and those that are more complex and physiologically relevant. The complexity of the model used shall be guided by the biological question to be addressed. This review provides an overview of the structure and function of the intestine and the models that are developed to emulate this. Conventional models are discussed in addition to emerging models which employ engineering principles to equip them with necessary advanced monitoring capabilities for intestinal host-pathogen interrogation. Limitations of current models and future perspectives on the field are presented.

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