The Effect of Dexmedetomidine on Postoperative Wound Healing in Neurosurgical Patients: A Meta-analysis

Overview

Journal Int Wound J

Specialties Emergency Medicine
Orthopedics

Date 2023 Dec 27

PMID 38148721

Authors

Congying Zhu

Donghang Cao

Lingyang Chen

Xuhang Zheng

Danjiang Lin

Affiliations

Soon will be listed here.

Abstract

This meta-analysis investigates the effect of dexmedetomidine on postoperative wound healing in neurosurgical patients. A thorough literature search resulted in the selection of seven studies from an initial pool of 1546 records. The analysis focused on wound healing outcomes, evaluated by the Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) scale and the Manchester Scar Scale (MSS). Results indicated significant improvements in the dexmedetomidine group: the REEDA scale scores at day seven post-surgery showed a Standardized Mean Difference group (SMD = -16.18, 95% CI: [-22.30, -10.06], p < 0.01), and the MSS scores at 3 months post-operation demonstrated an (SMD = -8.95, 95% CI: [-14.27, -3.62], p < 0.01). These findings suggest that dexmedetomidine may enhance wound healing and reduce scar formation in neurosurgical patients. Bias assessment indicated a low risk of bias across the studies.

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