Mechanobiological Strategies to Augment Cancer Treatment

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Nov 29

PMID 38024751

Authors

Alka Kumari

S Manasa Veena

Rashmita Luha

Ajay Tijore

Affiliations

Soon will be listed here.

Abstract

Cancer cells exhibit aberrant extracellular matrix mechanosensing due to the altered expression of mechanosensory cytoskeletal proteins. Such aberrant mechanosensing of the tumor microenvironment (TME) by cancer cells is associated with disease development and progression. In addition, recent studies show that such mechanosensing changes the mechanobiological properties of cells, and in turn cells become susceptible to mechanical perturbations. Due to an increasing understanding of cell biomechanics and cellular machinery, several approaches have emerged to target the mechanobiological properties of cancer cells and cancer-associated cells to inhibit cancer growth and progression. In this Perspective, we summarize the progress in developing mechano-based approaches to target cancer by interfering with the cellular mechanosensing machinery and overall TME.

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