Electroconductivity, a Regenerative Engineering Approach to Reverse Rotator Cuff Muscle Degeneration

Overview

Journal Regen Biomater

Specialty Biomedical Engineering

Date 2023 Nov 29

PMID 38020235

Authors

Nikoo Saveh-Shemshaki

Mohammed A Barajaa

Takayoshi Otsuka

Elnaz S Mirdamadi

Lakshmi S Nair

Cato T Laurencin

Affiliations

Soon will be listed here.

Abstract

Muscle degeneration is one the main factors that lead to the high rate of retear after a successful repair of rotator cuff (RC) tears. The current surgical practices have failed to treat patients with chronic massive rotator cuff tears (RCTs). Therefore, regenerative engineering approaches are being studied to address the challenges. Recent studies showed the promising outcomes of electroactive materials (EAMs) on the regeneration of electrically excitable tissues such as skeletal muscle. Here, we review the most important biological mechanism of RC muscle degeneration. Further, the review covers the recent studies on EAMs for muscle regeneration including RC muscle. Finally, we will discuss the future direction toward the application of EAMs for the augmentation of RCTs.

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