The Role of Nanomaterials and Biological Agents on Rotator Cuff Regeneration

Overview

Journal Regen Eng Transl Med

Date 2022 Jan 10

PMID 35005215

Authors

Kenyatta S Washington

Nikoo Saveh Shemshaki

Cato T Laurencin

Affiliations

Soon will be listed here.

Abstract

The rotator cuff is a musculotendon unit responsible for movement in the shoulder. Rotator cuff tears represent a significant number of musculoskeletal injuries in the adult population. In addition, there is a high incidence of retear rates due to various complications within the complex anatomical structure and the lack of proper healing. Current clinical strategies for rotator cuff augmentation include surgical intervention with autograft tissue grafts and beneficial impacts have been shown, but challenges still exist because of limited supply. For decades, nanomaterials have been engineered for the repair of various tissue and organ systems. This review article provides a thorough summary of the role nanomaterials, stem cells and biological agents have played in rotator cuff repair to date and offers input on next generation approaches for regenerating this tissue.

Citing Articles

Fibroblast growth factor 8b (FGF-8b) enhances myogenesis and inhibits adipogenesis in rotator cuff muscle cell populations in vitro.

Otsuka T, Kan H, Mengsteab P, Tyson B, Laurencin C Proc Natl Acad Sci U S A. 2023; 121(1):e2314585121.

PMID: 38147545 PMC: 10769839. DOI: 10.1073/pnas.2314585121.

Electroconductivity, a regenerative engineering approach to reverse rotator cuff muscle degeneration.

Saveh-Shemshaki N, Barajaa M, Otsuka T, Mirdamadi E, Nair L, Laurencin C Regen Biomater. 2023; 10:rbad099.

PMID: 38020235 PMC: 10676522. DOI: 10.1093/rb/rbad099.

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Krupp R, Frankle M, Nyland J, Baker C, Werner B, St Pierre P Knee Surg Sports Traumatol Arthrosc. 2023; 31(7):2670-2680.

PMID: 36976315 DOI: 10.1007/s00167-023-07383-2.

Muscle degeneration in chronic massive rotator cuff tears of the shoulder: Addressing the real problem using a graphene matrix.

Shemshaki N, Kan H, Barajaa M, Otsuka T, Lebaschi A, Mishra N Proc Natl Acad Sci U S A. 2022; 119(33):e2208106119.

PMID: 35939692 PMC: 9388153. DOI: 10.1073/pnas.2208106119.

Regenerative engineering: a review of recent advances and future directions.

Esdaille C, Washington K, Laurencin C Regen Med. 2021; 16(5):495-512.

PMID: 34030463 PMC: 8356698. DOI: 10.2217/rme-2021-0016.

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