Quassinoids from Twigs of (Blanco) Merr and Their Anti-Parkinson's Disease Effect

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Nov 25

PMID 38003386

Authors

Min Cai

Xiao-Lin Bai

Hao-Jing Zang

Xiao-Han Tang

Ying Yan

Jia-Jia Wan

Min-You Peng

Hong Liang

Lin Liu

Feng Guo

Pei-Ji Zhao

Xun Liao

Ying-Tong Di

Xiao-Jiang Hao

Affiliations

Soon will be listed here.

Abstract

Six new C-20 and one new C-19 quassinoids, named perforalactones F-L (-), were isolated from twigs of . Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer-Villiger oxidation was proposed. Furthermore, the study evaluated the anti-Parkinson's disease potential of these C-20 quassinoids for the first time on 6-OHDA-induced PC12 cells and a Parkinson's disease model of . Perforalactones G and I ( and ) showed a 10-15% increase in cell viability of the model cells at 50 μM, while compounds and (100 μM) significantly improved the climbing ability of flies and increased the dopamine level in the brains and ATP content in the thoraces of the flies.

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