Jatrophane Diterpenoids from Linn. As Activators of Autophagy and Inhibitors of Tau Pathology

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jan 21

PMID 36674604

Authors

Ying Yan

Qi Zhou

Xiaoqian Ran

Qingyun Lu

Cuishan Zhang

Mingyou Peng

Lei Tang

Rongcan Luo

Yingtong Di

Xiaojiang Hao

Affiliations

Soon will be listed here.

Abstract

Ten jatrophane diterpenoids were isolated from the whole plant Linn. including seven new ones, named euphjatrophanes A-G (labeled compounds , , -). Their structures were elucidated with a combination of spectroscopic and single-crystal X-ray crystallography, enabling the identification of compounds , , and as the previously published euphpepluones G, K, and L, respectively. All compounds were evaluated for their bioactivity with flow cytometry in assays of autophagic flux in HM Cherry-GFP-LC3 (human microglia cells stably expressing the tandem monomeric mCherry-GFP-tagged LC3) cells. Euphpepluone K () significantly activated autophagic flux, an effect that was verified with confocal analysis. Moreover, cellular assays showed that euphpepluone K () induced autophagy and inhibited Tau pathology.

Citing Articles

Quassinoids from Twigs of (Blanco) Merr and Their Anti-Parkinson's Disease Effect.

Cai M, Bai X, Zang H, Tang X, Yan Y, Wan J Int J Mol Sci. 2023; 24(22).

PMID: 38003386 PMC: 10671724. DOI: 10.3390/ijms242216196.

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