Perforalactones D and E, Two New C-20 Quassinoids with Potential Activity to Induce Lysosomal Biogenesis from the Twigs of (Blanco) Merr

Two new quassinoids (1 and 2) were isolated from the twigs of (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1α,12α:5α,13α-dicyclo-9βH-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.