New Types of Magnetic Nanoparticles for Stimuli-Responsive Theranostic Nanoplatforms

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2023 Nov 21

PMID 37988692

Authors

Shuren Wang

Yanglong Hou

Affiliations

Soon will be listed here.

Abstract

Magnetic nanomaterials have played a crucial role in promoting the application of nanotechnology in the biomedical field. Although conventional magnetic nanomaterials such as iron oxide nanoparticles (NPs) are used as biosensors, drug delivery vehicles, diagnostic and treatment agents for several diseases, the persistent pursuit of high-performance technologies has prompted researchers to continuously develop new types of magnetic nanomaterials such as iron carbide NPs. Considering their potential application in biomedicine, magnetic NPs responsive to exogenous or endogenous stimuli are developed, thereby enhancing their applicability in more complex versatile scenarios. In this review, the synthesis and surface modification of magnetic NPs are focused, particularly iron carbide NPs. Subsequently, exogenous and endogenous stimuli-responsive magnetic NP-based theranostic platforms are introduced, particularly focusing on nanozyme-based technologies and magnetic NP-mediated immunotherapy, which are emerging stimuli-responsive treatments. Finally, the challenges and perspectives of magnetic NPs to accelerate future research in this field are discussed.

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References

Intlekofer A, Takemoto N, Wherry E, Longworth S, Northrup J, Palanivel V . Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005; 6(12):1236-44. DOI: 10.1038/ni1268. View

Rosenberg J, Bambury R, Van Allen E, Drabkin H, Lara Jr P, Harzstark A . A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma. Invest New Drugs. 2013; 32(1):178-87. PMC: 4560460. DOI: 10.1007/s10637-013-0045-6. View

Wang Z, Ju Y, Ali Z, Yin H, Sheng F, Lin J . Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics. Nat Commun. 2019; 10(1):4418. PMC: 6765052. DOI: 10.1038/s41467-019-12142-4. View

Gao J, Gu H, Xu B . Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. Acc Chem Res. 2009; 42(8):1097-107. DOI: 10.1021/ar9000026. View

Pham V, Kim D, Ko S . Oxidative degradation of the antibiotic oxytetracycline by Cu@FeO core-shell nanoparticles. Sci Total Environ. 2018; 631-632:608-618. DOI: 10.1016/j.scitotenv.2018.03.067. View

Yu X, Shavel A, An X, Luo Z, Ibanez M, Cabot A . Cu(2)ZnSnS(4)-Pt and Cu(2)ZnSnS(4)-Au heterostructured nanoparticles for photocatalytic water splitting and pollutant degradation. J Am Chem Soc. 2014; 136(26):9236-9. DOI: 10.1021/ja502076b. View

Topalian S, Drake C, Pardoll D . Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell. 2015; 27(4):450-61. PMC: 4400238. DOI: 10.1016/j.ccell.2015.03.001. View

Meffre A, Mehdaoui B, Kelsen V, Fazzini P, Carrey J, Lachaize S . A simple chemical route toward monodisperse iron carbide nanoparticles displaying tunable magnetic and unprecedented hyperthermia properties. Nano Lett. 2012; 12(9):4722-8. DOI: 10.1021/nl302160d. View

Zhang Z, Song S . Thermosensitive/superparamagnetic iron oxide nanoparticle-loaded nanocapsule hydrogels for multiple cancer hyperthermia. Biomaterials. 2016; 106:13-23. DOI: 10.1016/j.biomaterials.2016.08.015. View

10.

Bae K, Park M, Do M, Lee N, Ryu J, Kim G . Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia. ACS Nano. 2012; 6(6):5266-73. DOI: 10.1021/nn301046w. View

11.

Fonseca N, Rodrigues A, Rodrigues-Santos P, Alves V, Gregorio A, Valerio-Fernandes A . Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination. Biomaterials. 2015; 69:76-88. DOI: 10.1016/j.biomaterials.2015.08.007. View

12.

Fan W, Yung B, Huang P, Chen X . Nanotechnology for Multimodal Synergistic Cancer Therapy. Chem Rev. 2017; 117(22):13566-13638. DOI: 10.1021/acs.chemrev.7b00258. View

13.

Wei H, Wang E . Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes. Chem Soc Rev. 2013; 42(14):6060-93. DOI: 10.1039/c3cs35486e. View

14.

Dolmans D, Fukumura D, Jain R . Photodynamic therapy for cancer. Nat Rev Cancer. 2003; 3(5):380-7. DOI: 10.1038/nrc1071. View

15.

Yu J, Zhao F, Gao W, Yang X, Ju Y, Zhao L . Magnetic Reactive Oxygen Species Nanoreactor for Switchable Magnetic Resonance Imaging Guided Cancer Therapy Based on pH-Sensitive FeC@FeO Nanoparticles. ACS Nano. 2019; 13(9):10002-10014. DOI: 10.1021/acsnano.9b01740. View

16.

Muhlberger M, Janko C, Unterweger H, Friedrich R, Friedrich B, Band J . Functionalization Of T Lymphocytes With Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles For Magnetically Controlled Immune Therapy. Int J Nanomedicine. 2019; 14:8421-8432. PMC: 6817714. DOI: 10.2147/IJN.S218488. View

17.

Amedei A, Prisco D, D Elios M . The use of cytokines and chemokines in the cancer immunotherapy. Recent Pat Anticancer Drug Discov. 2012; 8(2):126-42. View

18.

Lee H, Shin T, Cheon J, Weissleder R . Recent Developments in Magnetic Diagnostic Systems. Chem Rev. 2015; 115(19):10690-724. PMC: 5791529. DOI: 10.1021/cr500698d. View

19.

Xu C, Pu K . Second near-infrared photothermal materials for combinational nanotheranostics. Chem Soc Rev. 2020; 50(2):1111-1137. DOI: 10.1039/d0cs00664e. View

20.

Lorkowski M, Atukorale P, Ghaghada K, Karathanasis E . Stimuli-Responsive Iron Oxide Nanotheranostics: A Versatile and Powerful Approach for Cancer Therapy. Adv Healthc Mater. 2020; 10(5):e2001044. PMC: 7933107. DOI: 10.1002/adhm.202001044. View