Innovative Nanoparticle-based Approaches for Modulating Neutrophil Extracellular Traps in Diseases: from Mechanisms to Therapeutics

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Date 2025 Feb 6

PMID 39915767

Authors

Haisong Li

Can Li

Cong Fu

Yizhuo Wang

Tingting Liang

Haitao Wu

Chenxi Wu

Chang Wang

Tianmeng Sun

Shuhan Liu

Affiliations

Soon will be listed here.

Abstract

Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, and tumors. While they help capture and eliminate pathogens, NETs' excessive or dysregulated formation can lead to tissue damage and disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly in achieving precise drug delivery and maintaining drug stability. Nanoparticle (NP)-based drug delivery systems offer innovative solutions for overcoming the limitations of conventional therapies. This review explores the biological mechanisms of NET formation, their interactions with NPs, and the therapeutic applications of NP-based drug delivery systems for modulating NETs. We discuss how NPs can be designed to either promote or inhibit NET formation and provide a comprehensive analysis of their potential in treating NET-related diseases. Additionally, we address the current challenges and future prospects for NP-based therapies in NET research, aiming to bridge the gap between nanotechnology and NET modulation for the development of novel therapeutic approaches.

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