Associations of Free, Bioavailable and Total 25-hydroxyvitamin D with Neonatal Birth Anthropometry and Calcium Homoeostasis in Mother-child Pairs in a Sunny Mediterranean Region

Overview

Journal Br J Nutr

Specialty Nutritional Sciences

Date 2023 Oct 26

PMID 37880994

Authors

Hana M A Fakhoury

Tarek Ziad Arabi

Hani Tamim

Rene F Chun

William B Grant

Martin Hewison

Fatme AlAnouti

Stefan Pilz

Cedric Annweiler

Georgios Tzimagiorgis

Costas Haitoglou

Spyridon N Karras

Affiliations

Soon will be listed here.

Abstract

Sufficient vitamin D status is crucial for successful pregnancy and fetal development. The assessment of 25-hydroxyvitamin D (25(OH)D) concentrations is commonly used to evaluate vitamin D status. Our objective was to examine the interrelated biodynamics of maternal and neonatal total, free and bioavailable 25(OH)D in maternal-neonatal dyads at birth and their associations with homeostasis and neonatal birth anthropometry. We analysed a cohort of seventy full-term mother-child pairs. We found positive associations between all neonatal measures of vitamin D status. Maternal forms exhibited a similar pattern of association, except for the bioavailable maternal form. In multivariate analysis, both total and free maternal 25(OH)D concentrations were correlated with all neonatal forms (neonatal total 25(OH)D: 1·29 (95 % CI, 1·12, 1·46) for maternal total 25(OH)D, 10·89 (8·16, 13·63) for maternal free 25(OH)D), (neonatal free 25(OH)D: 0·15 for maternal total 25(OH)D, 1·28 (95 % CI, 0·89, 1·68) for maternal free 25(OH)D) and (0·13 (95 % CI, 0·10, 0·16), 1·06 (95 % CI, 0·68, 1·43) for maternal free 25(OH)D), respectively, with the exclusion of the bioavailable maternal form. We observed no significant interactions within or between groups regarding maternal and neonatal vitamin D parameters and maternal calcium and parathyroid hormone concentrations, and neonatal birth anthropometry. Our study indicates that bioavailable maternal and neonatal 25(OH)D have no significant effects on vitamin D equilibrium, Ca homeostasis and neonatal anthropometry at birth. However, we observed an interaction between maternal and neonatal total and free 25(OH)D concentrations at the maternal-neonatal interface, with no associations observed with other calciotropic or anthropometric outcomes.

Citing Articles

Associations between total, free and bioavailable 25-hydroxyvitamin D forms with adiponectin and irisin in maternal-neonatal pairs at birth from Greece.

Arabi T, Fakhoury H, Tamim H, Chun R, Hewison M, AlAnouti F Front Endocrinol (Lausanne). 2024; 15:1397869.

PMID: 39036056 PMC: 11257903. DOI: 10.3389/fendo.2024.1397869.

References

Wang C, Gao J, Yu S, Qiu L, Zeng L, Wang D . [Correlation between neonatal vitamin D level and maternal vitamin D level]. Zhongguo Dang Dai Er Ke Za Zhi. 2016; 18(1):20-3. PMC: 7390100. View

Vicic V, Kukec A, Kugler S, Gersak K, Osredkar J, Pandel Mikus R . Assessment of Vitamin D Status in Slovenian Premenopausal and Postmenopausal Women, Using Total, Free, and Bioavailable 25-Hydroxyvitamin D (25(OH)D). Nutrients. 2022; 14(24). PMC: 9784017. DOI: 10.3390/nu14245349. View

Palacios C, Kostiuk L, Pena-Rosas J . Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019; 7:CD008873. PMC: 6659840. DOI: 10.1002/14651858.CD008873.pub4. View

Moller U, Streym S, Mosekilde L, Heickendorff L, Flyvbjerg A, Frystyk J . Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum: a controlled cohort study. Osteoporos Int. 2012; 24(4):1307-20. DOI: 10.1007/s00198-012-2062-2. View

Mantecon L, Alonso M, Moya V, Andres A, Avello N, Martinez-Morillo E . Marker of vitamin D status in healthy children: Free or total 25-hydroxyvitamin D?. PLoS One. 2018; 13(8):e0202237. PMC: 6107142. DOI: 10.1371/journal.pone.0202237. View

Wang Y, Li H, Zheng M, Wu Y, Zeng T, Fu J . Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: A prospective cohort study. PLoS One. 2018; 13(4):e0195700. PMC: 5915779. DOI: 10.1371/journal.pone.0195700. View

Tsuprykov O, Buse C, Skoblo R, Hocher B . Comparison of free and total 25-hydroxyvitamin D in normal human pregnancy. J Steroid Biochem Mol Biol. 2019; 190:29-36. DOI: 10.1016/j.jsbmb.2019.03.008. View

Farrant H, Krishnaveni G, Hill J, Boucher B, Fisher D, Noonan K . Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr. 2008; 63(5):646-52. PMC: 2678985. DOI: 10.1038/ejcn.2008.14. View

El Rifai N, Moety G, Gaafar H, Hamed D . Vitamin D deficiency in Egyptian mothers and their neonates and possible related factors. J Matern Fetal Neonatal Med. 2013; 27(10):1064-8. DOI: 10.3109/14767058.2013.849240. View

10.

Kim H, Kim J, Jung M, Cho I, Kim Y, Cho M . Clinical Usefulness of Bioavailable Vitamin D and Impact of Genotyping on the Determination of Bioavailable Vitamin D in a Korean Population. Int J Endocrinol. 2019; 2019:9120467. PMC: 6350553. DOI: 10.1155/2019/9120467. View

11.

Bowyer L, Catling-Paull C, Diamond T, Homer C, Davis G, Craig M . Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol (Oxf). 2008; 70(3):372-7. DOI: 10.1111/j.1365-2265.2008.03316.x. View

12.

Best C, Pressman E, Queenan R, Cooper E, OBrien K . Longitudinal changes in serum vitamin D binding protein and free 25-hydroxyvitamin D in a multiracial cohort of pregnant adolescents. J Steroid Biochem Mol Biol. 2018; 186:79-88. PMC: 6611677. DOI: 10.1016/j.jsbmb.2018.09.019. View

13.

Turkes G, Uysal S, Demir T, Demiral Y, Pamuk B, Yilmaz H . Associations Between Bioavailable Vitamin D and Remnant Cholesterol in Patients With Type 2 Diabetes Mellitus. Cureus. 2021; 13(2):e13248. PMC: 7948319. DOI: 10.7759/cureus.13248. View

14.

Shah I, Petroczi A, Naughton D . Method for simultaneous analysis of eight analogues of vitamin D using liquid chromatography tandem mass spectrometry. Chem Cent J. 2012; 6(1):112. PMC: 3505479. DOI: 10.1186/1752-153X-6-112. View

15.

Prentice A . Vitamin D deficiency: a global perspective. Nutr Rev. 2008; 66(10 Suppl 2):S153-64. DOI: 10.1111/j.1753-4887.2008.00100.x. View

16.

Tamblyn J, Hewison M, Wagner C, Bulmer J, Kilby M . Immunological role of vitamin D at the maternal-fetal interface. J Endocrinol. 2015; 224(3):R107-21. DOI: 10.1530/JOE-14-0642. View

17.

Fernando M, Ellery S, Marquina C, Lim S, Naderpoor N, Mousa A . Vitamin D-Binding Protein in Pregnancy and Reproductive Health. Nutrients. 2020; 12(5). PMC: 7285222. DOI: 10.3390/nu12051489. View

18.

Mumford S, Garbose R, Kim K, Kissell K, Kuhr D, Omosigho U . Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. Lancet Diabetes Endocrinol. 2018; 6(9):725-732. PMC: 6109429. DOI: 10.1016/S2213-8587(18)30153-0. View

19.

Pereira J, Chactoura J, Nohra F, Diogenes M, Bezerra F . Free and Bioavailable Fractions of Vitamin D: Association with Maternal Characteristics in Brazilian Pregnant Women. J Nutr Metab. 2020; 2020:1408659. PMC: 7519195. DOI: 10.1155/2020/1408659. View

20.

Pilz S, Zittermann A, Trummer C, Theiler-Schwetz V, Lerchbaum E, Keppel M . Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect. 2019; 8(2):R27-R43. PMC: 6365669. DOI: 10.1530/EC-18-0432. View