Electroactive Polymers for On-Demand Drug Release

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2023 Oct 20

PMID 37861058

Authors

Manal E Alkahtani

Moe Elbadawi

Christopher A R Chapman

Rylie A Green

Simon Gaisford

Mine Orlu

Abdul W Basit

Affiliations

Soon will be listed here.

Abstract

Conductive materials have played a significant role in advancing society into the digital era. Such materials are able to harness the power of electricity and are used to control many aspects of daily life. Conductive polymers (CPs) are an emerging group of polymers that possess metal-like conductivity yet retain desirable polymeric features, such as processability, mechanical properties, and biodegradability. Upon receiving an electrical stimulus, CPs can be tailored to achieve a number of responses, such as harvesting energy and stimulating tissue growth. The recent FDA approval of a CP-based material for a medical device has invigorated their research in healthcare. In drug delivery, CPs can act as electrical switches, drug release is achieved at a flick of a switch, thereby providing unprecedented control over drug release. In this review, recent developments in CP as electroactive polymers for voltage-stimuli responsive drug delivery systems are evaluated. The review demonstrates the distinct drug release profiles achieved by electroactive formulations, and both the precision and ease of stimuli response. This level of dynamism promises to yield "smart medicines" and warrants further research. The review concludes by providing an outlook on electroactive formulations in drug delivery and highlighting their integral roles in healthcare IoT.

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References

Adepu S, Ramakrishna S . Controlled Drug Delivery Systems: Current Status and Future Directions. Molecules. 2021; 26(19). PMC: 8512302. DOI: 10.3390/molecules26195905. View

Svirskis D, Travas-Sejdic J, Rodgers A, Garg S . Electrochemically controlled drug delivery based on intrinsically conducting polymers. J Control Release. 2010; 146(1):6-15. DOI: 10.1016/j.jconrel.2010.03.023. View

Zare E, Makvandi P, Ashtari B, Rossi F, Motahari A, Perale G . Progress in Conductive Polyaniline-Based Nanocomposites for Biomedical Applications: A Review. J Med Chem. 2019; 63(1):1-22. DOI: 10.1021/acs.jmedchem.9b00803. View

Sahoo J, Sarkhel S, Mukherjee N, Jaiswal A . Nanomaterial-Based Antimicrobial Coating for Biomedical Implants: New Age Solution for Biofilm-Associated Infections. ACS Omega. 2022; 7(50):45962-45980. PMC: 9773971. DOI: 10.1021/acsomega.2c06211. View

Czerwinska-Glowka D, Przystas W, Zablocka-Godlewska E, Student S, Cwalina B, Lapkowski M . Electrically-responsive antimicrobial coatings based on a tetracycline-loaded poly(3,4-ethylenedioxythiophene) matrix. Mater Sci Eng C Mater Biol Appl. 2021; 123:112017. DOI: 10.1016/j.msec.2021.112017. View

Huang H, Tsai Y, Lin S, Hsu S . Smart polymers for cell therapy and precision medicine. J Biomed Sci. 2019; 26(1):73. PMC: 6798433. DOI: 10.1186/s12929-019-0571-4. View

Zamboni F, Ryan E, Culebras M, Collins M . Labile crosslinked hyaluronic acid via urethane formation using bis(β-isocyanatoethyl) disulphide with tuneable physicochemical and immunomodulatory properties. Carbohydr Polym. 2020; 245:116501. DOI: 10.1016/j.carbpol.2020.116501. View

Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R . Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2020; 20(2):101-124. PMC: 7717100. DOI: 10.1038/s41573-020-0090-8. View

Zhao X, Chen F, Li Y, Lu H, Zhang N, Ma M . Bioinspired ultra-stretchable and anti-freezing conductive hydrogel fibers with ordered and reversible polymer chain alignment. Nat Commun. 2018; 9(1):3579. PMC: 6123392. DOI: 10.1038/s41467-018-05904-z. View

10.

Zamboni F, Wong C, Collins M . Hyaluronic acid association with bacterial, fungal and viral infections: Can hyaluronic acid be used as an antimicrobial polymer for biomedical and pharmaceutical applications?. Bioact Mater. 2022; 19:458-473. PMC: 9079116. DOI: 10.1016/j.bioactmat.2022.04.023. View

11.

Shah S, Firlak M, Berrow S, Halcovitch N, Baldock S, Yousafzai B . Electrochemically Enhanced Drug Delivery Using Polypyrrole Films. Materials (Basel). 2018; 11(7). PMC: 6073109. DOI: 10.3390/ma11071123. View

12.

Ligon S, Liska R, Stampfl J, Gurr M, Mulhaupt R . Polymers for 3D Printing and Customized Additive Manufacturing. Chem Rev. 2017; 117(15):10212-10290. PMC: 5553103. DOI: 10.1021/acs.chemrev.7b00074. View

13.

Miar S, Ong J, Bizios R, Guda T . Electrically Stimulated Tunable Drug Delivery From Polypyrrole-Coated Polyvinylidene Fluoride. Front Chem. 2021; 9:599631. PMC: 7892451. DOI: 10.3389/fchem.2021.599631. View

14.

Saravanakumar K, Park S, Santosh S, Ganeshalingam A, Thiripuranathar G, Sathiyaseelan A . Application of hyaluronic acid in tissue engineering, regenerative medicine, and nanomedicine: A review. Int J Biol Macromol. 2022; 222(Pt B):2744-2760. DOI: 10.1016/j.ijbiomac.2022.10.055. View

15.

Luo Z, Dai Y, Gao H . Development and application of hyaluronic acid in tumor targeting drug delivery. Acta Pharm Sin B. 2019; 9(6):1099-1112. PMC: 6900560. DOI: 10.1016/j.apsb.2019.06.004. View

16.

How K, Yap W, Lim C, Goh B, Lai Z . Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review. Front Pharmacol. 2020; 11:1105. PMC: 7397973. DOI: 10.3389/fphar.2020.01105. View

17.

Kleber C, Lienkamp K, Ruhe J, Asplund M . Electrochemically Controlled Drug Release from a Conducting Polymer Hydrogel (PDMAAp/PEDOT) for Local Therapy and Bioelectronics. Adv Healthc Mater. 2019; 8(10):e1801488. DOI: 10.1002/adhm.201801488. View

18.

Boehler C, Asplund M . A detailed insight into drug delivery from PEDOT based on analytical methods: effects and side effects. J Biomed Mater Res A. 2014; 103(3):1200-7. PMC: 4342763. DOI: 10.1002/jbm.a.35252. View

19.

Puiggali-Jou A, Del Valle L, Aleman C . Drug delivery systems based on intrinsically conducting polymers. J Control Release. 2019; 309:244-264. DOI: 10.1016/j.jconrel.2019.07.035. View

20.

Patra J, Das G, Fraceto L, Campos E, Del Pilar Rodriguez-Torres M, Acosta-Torres L . Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018; 16(1):71. PMC: 6145203. DOI: 10.1186/s12951-018-0392-8. View