Nano Based Drug Delivery Systems: Recent Developments and Future Prospects

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2018 Sep 21

PMID 30231877

Citations 1535

Authors

Jayanta Kumar Patra

Gitishree Das

Leonardo Fernandes Fraceto

Estefania Vangelie Ramos Campos

Maria Del Pilar Rodriguez-Torres

Laura Susana Acosta-Torres

Luis Armando Diaz-Torres

Renato Grillo

Mallappa Kumara Swamy

Shivesh Sharma

Solomon Habtemariam

Han-Seung Shin

Affiliations

Soon will be listed here.

Abstract

Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.

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References

Xu L, Qiu L, Sheng Y, Sun Y, Deng L, Li X . Biodegradable pH-responsive hydrogels for controlled dual-drug release. J Mater Chem B. 2020; 6(3):510-517. DOI: 10.1039/c7tb01851g. View

de Jong W, Borm P . Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine. 2008; 3(2):133-49. PMC: 2527668. DOI: 10.2147/ijn.s596. View

Madaan K, Kumar S, Poonia N, Lather V, Pandita D . Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues. J Pharm Bioallied Sci. 2014; 6(3):139-50. PMC: 4097927. DOI: 10.4103/0975-7406.130965. View

Kesharwani P, Xie L, Banerjee S, Mao G, Padhye S, Sarkar F . Hyaluronic acid-conjugated polyamidoamine dendrimers for targeted delivery of 3,4-difluorobenzylidene curcumin to CD44 overexpressing pancreatic cancer cells. Colloids Surf B Biointerfaces. 2015; 136:413-23. DOI: 10.1016/j.colsurfb.2015.09.043. View

Guo Y, Zhang Y, Ma J, Li Q, Li Y, Zhou X . Light/magnetic hyperthermia triggered drug released from multi-functional thermo-sensitive magnetoliposomes for precise cancer synergetic theranostics. J Control Release. 2017; 272:145-158. DOI: 10.1016/j.jconrel.2017.04.028. View

Lin P, Lin S, Wang P, Sridhar R . Techniques for physicochemical characterization of nanomaterials. Biotechnol Adv. 2013; 32(4):711-26. PMC: 4024087. DOI: 10.1016/j.biotechadv.2013.11.006. View

Silva M, Calado R, Marto J, Bettencourt A, Almeida A, Goncalves L . Chitosan Nanoparticles as a Mucoadhesive Drug Delivery System for Ocular Administration. Mar Drugs. 2017; 15(12). PMC: 5742830. DOI: 10.3390/md15120370. View

Ouattara B, Simard R, Holley R, Piette G, Begin A . Antibacterial activity of selected fatty acids and essential oils against six meat spoilage organisms. Int J Food Microbiol. 1997; 37(2-3):155-62. DOI: 10.1016/s0168-1605(97)00070-6. View

Anirudhan T, Nair A . Temperature and ultrasound sensitive gatekeepers for the controlled release of chemotherapeutic drugs from mesoporous silica nanoparticles. J Mater Chem B. 2020; 6(3):428-439. DOI: 10.1039/c7tb02292a. View

10.

Swierczewska M, Han H, Kim K, Park J, Lee S . Polysaccharide-based nanoparticles for theranostic nanomedicine. Adv Drug Deliv Rev. 2015; 99(Pt A):70-84. PMC: 4798864. DOI: 10.1016/j.addr.2015.11.015. View

11.

Kudr J, Haddad Y, Richtera L, Heger Z, cernak M, Adam V . Magnetic Nanoparticles: From Design and Synthesis to Real World Applications. Nanomaterials (Basel). 2017; 7(9). PMC: 5618354. DOI: 10.3390/nano7090243. View

12.

Bobo D, Robinson K, Islam J, Thurecht K, Corrie S . Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date. Pharm Res. 2016; 33(10):2373-87. DOI: 10.1007/s11095-016-1958-5. View

13.

Huang C, Huang C, Mai F, Yen C, Tzing S, Hsieh H . Application of paramagnetic graphene quantum dots as a platform for simultaneous dual-modality bioimaging and tumor-targeted drug delivery. J Mater Chem B. 2020; 3(4):651-664. DOI: 10.1039/c4tb01650e. View

14.

Lounnas V, Ritschel T, Kelder J, McGuire R, Bywater R, Foloppe N . Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery. Comput Struct Biotechnol J. 2014; 5:e201302011. PMC: 3962124. DOI: 10.5936/csbj.201302011. View

15.

Muller J, Bauer K, Prozeller D, Simon J, Mailander V, Wurm F . Coating nanoparticles with tunable surfactants facilitates control over the protein corona. Biomaterials. 2016; 115:1-8. DOI: 10.1016/j.biomaterials.2016.11.015. View

16.

Anselmo A, Mitragotri S . Nanoparticles in the clinic. Bioeng Transl Med. 2018; 1(1):10-29. PMC: 5689513. DOI: 10.1002/btm2.10003. View

17.

Hervault A, Thanh N . Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer. Nanoscale. 2014; 6(20):11553-73. DOI: 10.1039/c4nr03482a. View

18.

Golovin Y, Gribanovsky S, Golovin D, Klyachko N, Majouga A, Master A . Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields. J Control Release. 2015; 219:43-60. PMC: 4841691. DOI: 10.1016/j.jconrel.2015.09.038. View

19.

Yhee J, Son S, Kim S, Park K, Choi K, Kwon I . Self-assembled glycol chitosan nanoparticles for disease-specific theranostics. J Control Release. 2014; 193:202-13. DOI: 10.1016/j.jconrel.2014.05.009. View

20.

Podgorna K, Szczepanowicz K, Piotrowski M, Gajdosova M, Stepanek F, Warszynski P . Gadolinium alginate nanogels for theranostic applications. Colloids Surf B Biointerfaces. 2017; 153:183-189. DOI: 10.1016/j.colsurfb.2017.02.026. View