The Neutrophil-to-lymphocyte Ratio As a New Prognostic Factor in Cancers: a Narrative Review

Overview

Journal Front Oncol

Specialty Oncology

Date 2023 Oct 20

PMID 37860198

Authors

Kian Heshmat-Ghahdarijani

Vida Sarmadi

Afshin Heidari

Alireza Falahati Marvasti

Sina Neshat

Sina Raeisi

Affiliations

Soon will be listed here.

Abstract

The increasing incidence of cancer globally has highlighted the significance of early diagnosis and improvement of treatment strategies. In the 19th century, a connection was made between inflammation and cancer, with inflammation recognized as a malignancy hallmark. The neutrophil-to-lymphocyte ratio (NLR), calculated from a complete blood count, is a simple and accessible biomarker of inflammation status. NLR has also been proven to be a prognostic factor for various medical conditions, including mortality classification in cardiac patients, infectious diseases, postoperative complications, and inflammatory states. In this narrative review, we aim to assess the prognostic potential of NLR in cancer. We will review recent studies that have evaluated the association between NLR and various malignancies. The results of this review will help to further understand the role of NLR in cancer prognosis and inform future research directions. With the increasing incidence of cancer, it is important to identify reliable and accessible prognostic markers to improve patient outcomes. The study of NLR in cancer may provide valuable insights into the development and progression of cancer and inform clinical decision-making.

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