Neutrophil to Lymphocyte Ratio Predict Mortality and Major Adverse Cardiac Events in Acute Coronary Syndrome: A Systematic Review and Meta-analysis

Overview

Journal Clin Biochem

Specialty Biochemistry

Date 2017 Nov 15

PMID 29132766

Citations 70

Authors

Chao-Hui Dong

Zhang-Min Wang

Si-Yu Chen

Affiliations

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Abstract

Objectives: Neutrophil to lymphocyte ratio (NLR) might be associated with the mortality or major adverse cardiac events (MACEs) in acute coronary syndrome (ACS) patients. We performed a meta-analysis to evaluate the correlation between NLR and mortality/MACEs in ACS.

Methods: We assessed clinical trials through Pubmed, EMBASE, the Cochrane Library and Web of science in investigating the association between NLR and mortality/MACEs in ACS patients up to August 15, 2017. The primary outcome was mortality or recurrent MACEs.

Results: In total, 8 studies of 9406 patients were included in the systematic and meta-analysis. Our analysis indicated that elevated pretreatment NLR was a poor prognostic marker for patients with recent ACS in predicting medium to long-term mortality/MACEs (OR 1.26, 95%CI 1.13-1.41). And the analysis indicated that higher pretreatment NLR value was associated with higher in-hospital mortality in ACS patients (OR 6.39, 95%CI 1.49-27.38, p<0.001). The NLR value of 5.0 maybe a cut-off value for ACS risk.

Conclusions: In patients with a recent ACS, an elevated pretreatment NLR value is effective in predicting the risk of mortality/MACEs.

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