Effects of Norepinephrine on Microglial Neuroinflammation and Neuropathic Pain

Overview

Journal Ibrain

Specialty Neurology

Date 2023 Oct 3

PMID 37786561

Authors

He-Lin Zou

Juan Li

Jun-Li Zhou

Xi Yi

Song Cao

Affiliations

Soon will be listed here.

Abstract

Norepinephrine (NE) is an important neurotransmitter in the central nervous system. NE is released from locus coeruleus neurons and is involved in a variety of physiological and pathological processes. Neuroinflammation is a common manifestation of many kinds of neurological diseases. The activation of microglia directly affects the status of neuroinflammation. Several kinds of adrenergic receptors, which anchor on microglia and can be regulated by NE, affect the activation of microglia and neuroinflammation. NE influences chronic pain, anxiety, and depression by regulating the activation of microglia.

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