-Aminoisobutyric Acid Relates to Favorable Glucose Metabolism Through Adiponectin in Adults with Obesity Independent of Prediabetes

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2023 Oct 2

PMID 37780967

Authors

Habiba Faiz

Emily M Heiston

Steven K Malin

Affiliations

Soon will be listed here.

Abstract

-Aminoisobutyric acid (BAIBA) is secreted by skeletal muscle and promotes insulin sensitivity, fat oxidation, and anti-inflammation. While BAIBA is purportedly lower in individuals with obesity, no work has examined if prediabetes (PD) differentially impacts BAIBA concentrations in people with obesity. . Adults were classified as normal glucose tolerant (NGT; = 22 (20F); 48.0 ± 2.4 yrs; 36.9 ± 1.2 kg/m) or PD ( = 23 (18F); 54.2 ± 1.6 yrs; 38.4 ± 1.2 kg/m) based on ADA criteria. A 180-minute 75 g OGTT was used to estimate fasting (HOMA-IR (liver)) and postprandial (Matsuda index (muscle)) insulin sensitivity as well as -cell function (disposition index (DI), glucose-stimulated insulin secretion adjusted for insulin sensitivity). Body composition and fasting measures of BAIBA, fat oxidation (indirect calorimetry), and adipokines were determined. . NGT and PD had similar BAIBA concentrations (1.4 ± 0.1 vs. 1.2 ± 0.1 M, = 0.23) and fat oxidation ( = 0.31), despite NGT having lower fasting (92.2 ± 1.2 vs. 104.1 ± 3.2 mg/dL, = 0.002) and tAUC glucose ( < 0.001) compared to PD. Moreover, NGT had higher postprandial insulin sensitivity ( = 0.01) and higher total phase DI ( = 0.003) and DI ( = 0.001). Increased BAIBA was associated with adiponectin ( = 0.37, = 0.02), adiponectin/leptin ratio ( = 0.39, = 0.01), and lower glucose and insulin at 180 minutes ( = -0.31, = 0.03 and = -0.39, = 0.03, respectively). Adiponectin also correlated with lower glucose at 180 minutes ( = -0.45, = 0.005), and mediation analysis showed that BAIBA was no longer a significant predictor of glucose at 180 minutes after controlling for adiponectin ( = 0.08). . While BAIBA did not differ between NGT and PD, higher BAIBA is related to favorable glucose metabolism, possibly through an adiponectin-related mechanism. Additional work is required to understand how exercise and/or diet impact BAIBA in relation to type 2 diabetes risk.

Citing Articles

New Mediators in the Crosstalk between Different Adipose Tissues.

Gomez-Hernandez A, de Las Heras N, Galvez B, Fernandez-Marcelo T, Fernandez-Millan E, Escribano O Int J Mol Sci. 2024; 25(9).

PMID: 38731880 PMC: 11083914. DOI: 10.3390/ijms25094659.

-Aminoisobutyric Acid Relates to Favorable Glucose Metabolism through Adiponectin in Adults with Obesity Independent of Prediabetes.

Faiz H, Heiston E, Malin S J Diabetes Res. 2023; 2023:4618215.

PMID: 37780967 PMC: 10539091. DOI: 10.1155/2023/4618215.

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