The Disposition Index: Adjustment for Peripheral Vs. Hepatic Insulin Sensitivity?

Overview

Journal J Physiol

Specialty Physiology

Date 2010 Jan 27

PMID 20100741

Citations 26

Authors

K Faerch

C Brons

A C Alibegovic

A Vaag

Affiliations

Soon will be listed here.

Abstract

The assessment of pancreatic beta cell function in humans is challenging because of a complex interplay between insulin secretion, insulin sensitivity and hepatic insulin extraction. Simplified, the relationship between insulin secretion and insulin sensitivity can be described by an approximate hyperbola with the product of the two variables being constant for individuals with the same degree of glucose tolerance (the disposition index). Strengths and limitations of the disposition index have been widely debated in the literature. In this review we will focus on another and until recently unrecognized dimension of the disposition index, namely the issue of adjusting insulin secretion for hepatic versus peripheral insulin sensitivity. An underlying assumption of this issue is that the liver as compared to muscle plays a different role in the regulation of in vivo insulin secretion.

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