Optogenetic Approach in Trigeminal Neuralgia and Potential Concerns: Preclinical Insights

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2023 Sep 29

PMID 37775720

Authors

Elina Kc

Jaisan Islam

Gabsang Lee

Young Seok Park

Affiliations

Soon will be listed here.

Abstract

The integration of optogenetics in the trigeminal pain circuitry broadens and reinforces existing pain investigations. Similar to research on spinal neuropathic pain, the exploration of the underlying determinants of orofacial pain is expanding. Optogenetics facilitates more direct, specific, and subtle investigations of the neuronal circuits involved in orofacial pain. One of the most significant concerns of both dentistry and medicine is trigeminal neuralgia (TN) management due to its substantial impact on a patient's quality of life. Our objective is to gather insights from preclinical studies conducted in TN employing an optogenetic paradigm, thereby extending the prospects for in-depth neurobiological research. This review highlights optogenetic research in trigeminal pain circuitry involving TN. We outline the central and peripheral regions associated with pain-that have been investigated using optogenetics in the trigeminal pain circuitry. The study further reports its scope and limitations as well as its potential for future applications from bench to bedside.

Citing Articles

Optogenetic inhibition of ventrolateral orbitofrontal cortex astrocytes facilitates ventrolateral periaqueductal gray glutamatergic activity to reduce hypersensitivity in infraorbital nerve injury rat model.

Islam J, Rahman M, Ali M, Kim H, Kc E, Park Y J Headache Pain. 2025; 26(1):41.

PMID: 39994518 PMC: 11854010. DOI: 10.1186/s10194-025-01977-6.

Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migraine and cluster headache.

Islam J, Rahman M, Ali M, Kc E, Park Y J Headache Pain. 2024; 25(1):205.

PMID: 39587517 PMC: 11587712. DOI: 10.1186/s10194-024-01914-z.

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