Insights on Covid-19 with Superimposed Pulmonary Histoplasmosis: The Possible Nexus

Overview

Journal Immun Inflamm Dis

Specialties Allergy & Immunology
Infectious Diseases

Date 2023 Sep 29

PMID 37773721

Authors

Yahya A Almutawif

Hayder M Al-Kuraishy

Ali I Al-Gareeb

Athanasios Alexiou

Marios Papadakis

Hamza M A Eid

Hebatallah M Saad

Gaber El-Saber Batiha

Affiliations

Soon will be listed here.

Abstract

A novel coronavirus (CoV) known as severe acute respiratory syndrome CoV type 2 is the causative agent for the development of CoV disease 2019 (Covid-19). Covid-19 may increase the risk of developing pulmonary histoplasmosis due to immune dysregulation. In addition, Covid-19 may enhance the propagation of acute pulmonary histoplasmosis due to lung injury and inflammation, and using corticosteroids in severely affected Covid-19 patients may reactivate latent pulmonary histoplasmosis. Likewise, activation of inflammatory signaling pathways during H. capsulatum infection may increase the severity of Covid-19 and vice versa. Furthermore, lymphopenia in Covid-19 may increase the risk for the progress of pulmonary histoplasmosis besides activation of inflammatory signaling pathways during H. capsulatum infection may increase the severity of Covid-19 and vice versa. Therefore, this critical review aimed to find the potential link between Covid-19 pneumonia and pulmonary histoplasmosis concerning the immunological response.

Citing Articles

Insights on Covid-19 with superimposed pulmonary histoplasmosis: The possible nexus.

Almutawif Y, Al-Kuraishy H, Al-Gareeb A, Alexiou A, Papadakis M, Eid H Immun Inflamm Dis. 2023; 11(9):e989.

PMID: 37773721 PMC: 10540147. DOI: 10.1002/iid3.989.

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