Phytochemical Constituents from the Seeds of Capsella Bursa-pastoris and Their Antioxidant Activities

Overview

Journal Plant Foods Hum Nutr

Specialties Biology
Nutritional Sciences

Date 2023 Sep 5

PMID 37668768

Authors

Ti-Qiang Zhou

Zhen-Zhen Wei

Jin-Rui Zhang

Jia-Hui Dong

Chun-Ying Liu

Cong-Zhi Jiang

Zi-Ming Xia

Si-Fan Liu

Min Li

Guang-Jie Zhang

Li Chen

Ying Tian

Bin Li

Shu-Chen Liu

Affiliations

Soon will be listed here.

Abstract

Phytochemical investigation of 70% EtOH extract of the seeds of Capsella bursa-pastoris led to the isolation of a new cyclobutane organic acid (1), and fourteen known compounds, including two organosulfur compounds (2, 3), two quinonoids (4, 5), five flavonoids (6-10), three sterols (11-13) and two other types (14, 15). The structures of the compounds were elucidated by extensive spectroscopic analyses as well as comparison of their spectroscopic data with those reported in the literature. The antioxidant capacities of all compounds and extractive fractions were evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging test and ferric reducing antioxidant power (FRAP) assay. Then the antioxidative substances were evaluated for their neuroprotective effects against HO-induced HT22 cell injury. The results indicated the strong scavenging ability to free radical of the extractive fractions and compounds 1-3, 8-10 and 13, and the ferric reducing antioxidant power of the extractive fractions and compounds 1-3, 8 and 10, which were close to or higher than that of the positive control trolox. The EtOAc fraction, n-BuOH fraction, and compounds 1, 3 and 8 can protect HT-22 cells from oxidative damage.

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