High-dose Vitamin D Supplementation is Related to an Improvement in Serum Alkaline Phosphatase in COVID-19 Patients; a Randomized Double-blinded Clinical Trial

Overview

Journal J Health Popul Nutr

Publisher Biomed Central

Specialties Nutritional Sciences
Public Health

Date 2023 Jul 25

PMID 37491318

Authors

Reza Rezvani Moghaddam

Zahra Khorasanchi

Ayad Rasool Noor

MohammadReza Shadmand Foumani Moghadam

Ali Jafarzadeh Esfahani

Abdullah Khalaf Merhej Alyakobi

MohammedHadi Lafta Alboresha

Payam Sharifan

Ali Bahari

Reza Rezvani

Malihe Aghasizade

Maryam Heshmati

Reza Assaran Darban

Gordon Ferns

Majid Ghayour Mobarhan

Affiliations

Soon will be listed here.

Abstract

Background: The benefits and harms of vitamin D supplementation in the treatment of COVID-19 have not yet been fully documented. In this study, we aimed to evaluate the effects of high-dose vitamin D supplementation on liver function tests in COVID-19.

Method: This double-blinded randomized clinical trial was conducted on 140 hospitalized patients aged > 30 years. Patients were randomly allocated to receive either intervention group (n = 70 receiving 50,000 IU of vitamin D capsules orally as a single dose and then 10,000 IU syrup daily from the second day of admission for 30 days) and the control group (n = 70 receiving 1000 IU vitamin D syrup orally per day). Liver function tests (LFT), including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and Lactate Dehydrogenase (LDH) were evaluated at baseline and at the end of the intervention. Decision tree analysis was performed to identify the predictors for change in liver enzymes.

Results: Among COVID-19 patients, a significant decrease was observed in serum level of ALP between intervention and placebo groups (p = 0.04). In addition, decision tree analysis revealed that GGT, temperature, serum magnesium level at baseline and gender were the most important predictors of ALT changes in COVID-19 patients.

Conclusion: High-dose vitamin D supplementation improved ALP markers among COVID-19 patients. More randomized controlled trials with longer follow-up times will be required.

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