KRAS Regulation of MiRNA: Stepping on the Brake to Go Faster

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2023 Jul 21

PMID 37478822

Authors

Clint A Stalnecker

Channing J Der

Affiliations

Soon will be listed here.

Abstract

In this issue of Molecular Cell, Shui et al. use a systems biology approach to unravel a paradoxical role of microRNA in oncogenic Kras regulation of gene and protein expression.

Citing Articles

Identification of Oncogene-Induced Senescence-Associated MicroRNAs.

Foutadakis S, Soureas K, Roupakia E, Besta S, Avgeris M, Kolettas E Methods Mol Biol. 2025; 2906:189-213.

PMID: 40082357 DOI: 10.1007/978-1-0716-4426-3_11.

The RAS oncogene in brain tumors and the involvement of let-7 microRNA.

Messina S Mol Biol Rep. 2024; 51(1):531.

PMID: 38637419 PMC: 11026240. DOI: 10.1007/s11033-024-09439-z.

References

Li X, Pritykin Y, Concepcion C, Lu Y, La Rocca G, Zhang M . High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down. Mol Cell. 2020; 79(1):167-179.e11. PMC: 7446397. DOI: 10.1016/j.molcel.2020.05.009. View

Golden R, Chen B, Li T, Braun J, Manjunath H, Chen X . An Argonaute phosphorylation cycle promotes microRNA-mediated silencing. Nature. 2017; 542(7640):197-202. PMC: 5302127. DOI: 10.1038/nature21025. View

La Rocca G, Olejniczak S, Gonzalez A, Briskin D, Vidigal J, Spraggon L . In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA. Proc Natl Acad Sci U S A. 2015; 112(3):767-72. PMC: 4311832. DOI: 10.1073/pnas.1424217112. View

Bartel D . Metazoan MicroRNAs. Cell. 2018; 173(1):20-51. PMC: 6091663. DOI: 10.1016/j.cell.2018.03.006. View

Brubaker D, Paulo J, Sheth S, Poulin E, Popow O, Joughin B . Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation. Cell Syst. 2019; 9(3):258-270.e6. PMC: 6816257. DOI: 10.1016/j.cels.2019.07.006. View