The Placental Function Beyond Pregnancy: Insights from Latin America

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2023 Jul 19

PMID 37466779

Authors

Ivo Carrasco-Wong

Marcelo Gonzalez-Ortiz

Gabriel Gomes Araujo

Victor V Lima

Fernanda R Giachini

Jana Stojanova

Alejandra Moller

Sebastian San Martin

Pablo Escudero

Alicia E Damiano

Martha Sosa-Macias

Carlos Galaviz-Hernandez

Enrique Teran

Carlos Escudero

Affiliations

Soon will be listed here.

Abstract

Currently, more than 100,000 papers had been published studying the placenta in both physiological and pathological contexts. However, relevant health conditions affecting placental function, mostly found in low-income countries, should be evaluated deeper. This review will raise some - of what we think necessary - points of discussion regarding challenging topics not fully understood, including the paternal versus maternal contribution on placental genes imprinting, placenta-brain communication, and some environmental conditions affecting the placenta. The discussions are parts of an international effort to fulfil some gaps observed in this area, and Latin-American research groups currently evaluate that.

Citing Articles

Editorial: The placenta: the origin of chronic diseases in adults.

Giachini F, Hryciw D, Castro-Parodi M, Damiano A Front Endocrinol (Lausanne). 2024; 15:1455965.

PMID: 39055061 PMC: 11269254. DOI: 10.3389/fendo.2024.1455965.

References

Adibi J, Whyatt R, Hauser R, Bhat H, Davis B, Calafat A . Transcriptional biomarkers of steroidogenesis and trophoblast differentiation in the placenta in relation to prenatal phthalate exposure. Environ Health Perspect. 2010; 118(2):291-6. PMC: 2831932. DOI: 10.1289/ehp.0900788. View

Amaya E, Gil F, Freire C, Olmedo P, Fernandez-Rodriguez M, Fernandez M . Placental concentrations of heavy metals in a mother-child cohort. Environ Res. 2012; 120:63-70. DOI: 10.1016/j.envres.2012.09.009. View

Amburgey O, Chapman A, May V, Bernstein I, Cipolla M . Plasma from preeclamptic women increases blood-brain barrier permeability: role of vascular endothelial growth factor signaling. Hypertension. 2010; 56(5):1003-8. PMC: 2959130. DOI: 10.1161/HYPERTENSIONAHA.110.158931. View

Andolf E, Sydsjo G, Bladh M, Berg G, Sharma S . Hypertensive disorders in pregnancy and later dementia: a Swedish National Register Study. Acta Obstet Gynecol Scand. 2017; 96(4):464-471. DOI: 10.1111/aogs.13096. View

Apostolidou S, Abu-Amero S, ODonoghue K, Frost J, Olafsdottir O, Chavele K . Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight. J Mol Med (Berl). 2006; 85(4):379-87. DOI: 10.1007/s00109-006-0131-8. View

Arbuckle T, Davis K, Marro L, Fisher M, Legrand M, LeBlanc A . Phthalate and bisphenol A exposure among pregnant women in Canada--results from the MIREC study. Environ Int. 2014; 68:55-65. DOI: 10.1016/j.envint.2014.02.010. View

Babak T, Deveale B, Tsang E, Zhou Y, Li X, Smith K . Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse. Nat Genet. 2015; 47(5):544-9. PMC: 4414907. DOI: 10.1038/ng.3274. View

Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L . Mammalian metallothioneins: properties and functions. Metallomics. 2012; 4(8):739-50. DOI: 10.1039/c2mt20081c. View

Barton S, Surani M, Norris M . Role of paternal and maternal genomes in mouse development. Nature. 1984; 311(5984):374-6. DOI: 10.1038/311374a0. View

10.

Benjamin S, Masai E, Kamimura N, Takahashi K, Anderson R, Faisal P . Phthalates impact human health: Epidemiological evidences and plausible mechanism of action. J Hazard Mater. 2017; 340:360-383. DOI: 10.1016/j.jhazmat.2017.06.036. View

11.

Brooks S, Fry R . Cadmium inhibits placental trophoblast cell migration via miRNA regulation of the transforming growth factor beta (TGF-β) pathway. Food Chem Toxicol. 2017; 109(Pt 1):721-726. PMC: 5656529. DOI: 10.1016/j.fct.2017.07.059. View

12.

Brusse I, Duvekot J, Jongerling J, Steegers E, de Koning I . Impaired maternal cognitive functioning after pregnancies complicated by severe pre-eclampsia: a pilot case-control study. Acta Obstet Gynecol Scand. 2008; 87(4):408-12. DOI: 10.1080/00016340801915127. View

13.

Burton G, Fowden A, Thornburg K . Placental Origins of Chronic Disease. Physiol Rev. 2016; 96(4):1509-65. PMC: 5504455. DOI: 10.1152/physrev.00029.2015. View

14.

Casas L, Fernandez M, Llop S, Guxens M, Ballester F, Olea N . Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children. Environ Int. 2011; 37(5):858-66. DOI: 10.1016/j.envint.2011.02.012. View

15.

Cerrillos L, Fernandez R, Machado M, Morillas I, Dahiri B, Paz S . Placental levels of metals and associated factors in urban and sub-urban areas of Seville (Spain). J Trace Elem Med Biol. 2019; 54:21-26. DOI: 10.1016/j.jtemb.2019.03.006. View

16.

Clemente D, Casas M, Janssen B, Lertxundi A, Santa-Marina L, Iniguez C . Prenatal ambient air pollution exposure, infant growth and placental mitochondrial DNA content in the INMA birth cohort. Environ Res. 2017; 157:96-102. DOI: 10.1016/j.envres.2017.05.018. View

17.

Court F, Tayama C, Romanelli V, Martin-Trujillo A, Iglesias-Platas I, Okamura K . Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment. Genome Res. 2014; 24(4):554-69. PMC: 3975056. DOI: 10.1101/gr.164913.113. View

18.

Crider K, Yang T, Berry R, Bailey L . Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role. Adv Nutr. 2012; 3(1):21-38. PMC: 3262611. DOI: 10.3945/an.111.000992. View

19.

Davies S, Lum J, Skouteris H, Byrne L, Hayden M . Cognitive impairment during pregnancy: a meta-analysis. Med J Aust. 2018; 208(1):35-40. DOI: 10.5694/mja17.00131. View

20.

Dayan N, Kaur A, Elharram M, Rossi A, Pilote L . Impact of Preeclampsia on Long-Term Cognitive Function. Hypertension. 2018; 72(6):1374-1380. DOI: 10.1161/HYPERTENSIONAHA.118.11320. View