High-fat-diet-associated Intestinal Microbiota Exacerbates Psoriasis-like Inflammation by Enhancing Systemic γδ T cell IL-17 Production

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2023 Jul 8

PMID 37421628

Authors

Koshiro Sonomoto

Rui Song

Daniel Eriksson

Anne M Hahn

Xianyi Meng

Pang Lyu

Shan Cao

Ning Liu

R Verena Taudte

Stefan Wirtz

Yoshiya Tanaka

Thomas H Winkler

Georg Schett

Didier Soulat

Aline Bozec

Affiliations

Soon will be listed here.

Abstract

Although it is known that psoriasis is strongly associated with obesity, the mechanistic connection between diet and skin lesions is not well established. Herein, we showed that only dietary fat, not carbohydrates or proteins, exacerbates psoriatic disease. Enhanced psoriatic skin inflammation was associated with changes in the intestinal mucus layer and microbiota composition by high-fat diet (HFD). Change of intestinal microbiota by vancomycin treatment effectively blocked activation of psoriatic skin inflammation by HFD, inhibited the systemic interleukin-17 (IL-17) response, and led to increased mucophilic bacterial species such as Akkermansia muciniphila. By using IL-17 reporter mice, we could show that HFD facilitates IL-17-mediated γδ T cell response in the spleen. Notably, oral gavage with live or heat-killed A. muciniphila effectively inhibited HFD-induced enhancement of psoriatic disease. In conclusion, HFD exacerbates psoriatic skin inflammation through changing the mucus barrier and the intestine microbial composition, which leads to an enhanced systemic IL-17 response.

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