: A Promising Probiotic Against Inflammation and Metabolic Disorders

Overview

Journal Virulence

Specialty Microbiology

Date 2024 Aug 28

PMID 39192579

Authors

Yanqing Zhao

Huijun Yang

Peng Wu

Shuguo Yang

Wenkun Xue

Biao Xu

Sirui Zhang

Bin Tang

Daoxiu Xu

Affiliations

Soon will be listed here.

Abstract

Metabolic disease is a worldwide epidemic that has become a public health problem. Gut microbiota is considered to be one of the important factors that maintain human health by regulating host metabolism. As an abundant bacterium in the host gut, regulates metabolic and immune functions, and protects gut health. Multiple studies have indicated that alterations in the abundance of are associated with various diseases, including intestinal inflammatory diseases, obesity, type 2 diabetes mellitus, and even parasitic diseases. Beneficial effects were observed not only in live , but also in pasteurized -derived extracellular vesicles, outer membrane, and secreted proteins. Although numerous studies have only proven the simple correlation between multiple diseases and , an increasing number of studies in animal models and preclinical models have demonstrated that the beneficial impacts shifted from correlations to in-depth mechanisms. In this review, we provide a comprehensive view of the beneficial effects of on different diseases and summarize the potential mechanisms of action of in the treatment of diseases. We provide a comprehensive understanding of for improving host health and discuss the perspectives of in the future studies.

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