Recapitulation of Pathophysiological Features of AD in SARS-CoV-2-infected Subjects

Overview

Journal Elife

Specialty Biology

Date 2023 Jul 7

PMID 37417740

Authors

Elizabeth Griggs

Kyle Trageser

Sean Naughton

Eun-Jeong Yang

Brian Mathew

Grace Van Hyfte

Linh Hellmers

Nathalie Jette

Molly Estill

Li Shen

Tracy Fischer

Giulio Maria Pasinetti

Affiliations

Soon will be listed here.

Abstract

Infection with the etiological agent of COVID-19, SARS-CoV-2, appears capable of impacting cognition in some patients with post-acute sequelae of SARS-CoV-2 (PASC). To evaluate neuropathophysiological consequences of SARS-CoV-2 infection, we examine transcriptional and cellular signatures in the Brodmann area 9 (BA9) of the frontal cortex and the hippocampal formation (HF) in SARS-CoV-2, Alzheimer's disease (AD), and SARS-CoV-2-infected AD individuals compared to age- and gender-matched neurological cases. Here, we show similar alterations of neuroinflammation and blood-brain barrier integrity in SARS-CoV-2, AD, and SARS-CoV-2-infected AD individuals. Distribution of microglial changes reflected by the increase in Iba-1 reveals nodular morphological alterations in SARS-CoV-2-infected AD individuals. Similarly, HIF-1α is significantly upregulated in the context of SARS-CoV-2 infection in the same brain regions regardless of AD status. The finding may help in informing decision-making regarding therapeutic treatments in patients with neuro-PASC, especially those at increased risk of developing AD.

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