Chromatin-Associated SIN3B Protects Cancer Cells from Genotoxic Stress-Induced Apoptosis and Dictates DNA Damage Repair Pathway Choice

Overview

Journal Mol Cancer Res

Specialty Cell Biology

Date 2023 Jun 14

PMID 37314748

Authors

Jorge Morales-Valencia

Coralie Petit

Alexander Calderon

Siddharth Saini

Gregory David

Affiliations

Soon will be listed here.

Abstract

Implications: Identifying SIN3B as a modulator of DNA damage repair choice provides novel potential therapeutic avenues to sensitize cancer cells to cytotoxic therapies.

References

Wang J, Gong Z, Chen J . MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol. 2011; 193(2):267-73. PMC: 3080258. DOI: 10.1083/jcb.201010026. View

Miller K, Tjeertes J, Coates J, Legube G, Polo S, Britton S . Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol. 2010; 17(9):1144-51. PMC: 3018776. DOI: 10.1038/nsmb.1899. View

Schrempf A, Slyskova J, Loizou J . Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy. Trends Cancer. 2020; 7(2):98-111. DOI: 10.1016/j.trecan.2020.09.007. View

Balciunaite E, Spektor A, Lents N, Cam H, Te Riele H, Scime A . Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Mol Cell Biol. 2005; 25(18):8166-78. PMC: 1234327. DOI: 10.1128/MCB.25.18.8166-8178.2005. View

Brinkman J, Liu Y, Kron S . Small-molecule drug repurposing to target DNA damage repair and response pathways. Semin Cancer Biol. 2020; 68:230-241. PMC: 7483256. DOI: 10.1016/j.semcancer.2020.02.013. View

Stavnezer J, Guikema J, Schrader C . Mechanism and regulation of class switch recombination. Annu Rev Immunol. 2008; 26:261-92. PMC: 2707252. DOI: 10.1146/annurev.immunol.26.021607.090248. View

Xu X, Stern D . NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 2003; 17(13):1842-8. DOI: 10.1096/fj.03-0310com. View

Bennardo N, Cheng A, Huang N, Stark J . Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet. 2008; 4(6):e1000110. PMC: 2430616. DOI: 10.1371/journal.pgen.1000110. View

Yuan C, Bu Y, Wang C, Yi F, Yang Z, Huang X . NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer. Mol Cell Biochem. 2011; 359(1-2):333-46. DOI: 10.1007/s11010-011-1027-7. View

10.

Garcia-Sanz P, Quintanilla A, Lafita M, Moreno-Bueno G, Garcia-Gutierrez L, Tabor V . Sin3b interacts with Myc and decreases Myc levels. J Biol Chem. 2014; 289(32):22221-36. PMC: 4139234. DOI: 10.1074/jbc.M113.538744. View

11.

Pommier Y, Leo E, Zhang H, Marchand C . DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol. 2010; 17(5):421-33. PMC: 7316379. DOI: 10.1016/j.chembiol.2010.04.012. View

12.

Nyberg K, Michelson R, Putnam C, Weinert T . Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet. 2002; 36:617-56. DOI: 10.1146/annurev.genet.36.060402.113540. View

13.

Lord C, Ashworth A . The DNA damage response and cancer therapy. Nature. 2012; 481(7381):287-94. DOI: 10.1038/nature10760. View

14.

Silverstein R, Ekwall K . Sin3: a flexible regulator of global gene expression and genome stability. Curr Genet. 2004; 47(1):1-17. DOI: 10.1007/s00294-004-0541-5. View

15.

Yang Z, Bu Y, Wang C, Liu G, Song F . Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells. Mol Cell Biochem. 2010; 342(1-2):1-6. DOI: 10.1007/s11010-010-0460-3. View

16.

Goldberg M, Stucki M, Falck J, DAmours D, Rahman D, Pappin D . MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature. 2003; 421(6926):952-6. DOI: 10.1038/nature01445. View

17.

Tang J, Cho N, Cui G, Manion E, Shanbhag N, Botuyan M . Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol. 2013; 20(3):317-25. PMC: 3594358. DOI: 10.1038/nsmb.2499. View

18.

Shanbhag N, Rafalska-Metcalf I, Balane-Bolivar C, Janicki S, Greenberg R . ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell. 2010; 141(6):970-81. PMC: 2920610. DOI: 10.1016/j.cell.2010.04.038. View

19.

Bainor A, Saini S, Calderon A, Casado-Polanco R, Giner-Ramirez B, Moncada C . The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence. Cell Rep. 2018; 25(10):2797-2807.e8. PMC: 6324198. DOI: 10.1016/j.celrep.2018.11.024. View

20.

Sallmyr A, Tomkinson A . Repair of DNA double-strand breaks by mammalian alternative end-joining pathways. J Biol Chem. 2018; 293(27):10536-10546. PMC: 6036210. DOI: 10.1074/jbc.TM117.000375. View