Structural and Spectroscopic Study of New Copper(II) and Zinc(II) Complexes of Coumarin Oxyacetate Ligands and Determination of Their Antimicrobial Activity

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Jun 10

PMID 37299035

Authors

Muhammad Mujahid

Natasha Trendafilova

Georgina Rosair

Kevin Kavanagh

Maureen Walsh

Bernadette S Creaven

Ivelina Georgieva

Affiliations

Soon will be listed here.

Abstract

Tackling antimicrobial resistance is of increasing concern in a post-pandemic world where overuse of antibiotics has increased the threat of another pandemic caused by antimicrobial-resistant pathogens. Derivatives of coumarins, a naturally occurring bioactive compound, and its metal complexes have proven therapeutic potential as antimicrobial agents and in this study a series of copper(II) and zinc(II) complexes of coumarin oxyacetate ligands were synthesised and characterised by spectroscopic techniques (IR, H, C NMR, UV-Vis) and by X-ray crystallography for two of the zinc complexes. The experimental spectroscopic data were then interpreted on the basis of molecular structure modelling and subsequent spectra simulation using the density functional theory method to identify the coordination mode in solution for the metal ions in the complexes. Interestingly, the solid-state coordination environment of the zinc complexes is in good agreement with the simulated solution state, which has not been the case in our previous studies of these ligands when coordinated to silver(I). Previous studies had indicated excellent antimicrobial activity for Ag(I) analogues of these ligands and related copper and zinc complexes of coumarin-derived ligands, but in this study none of the complexes displayed antimicrobial activity against the clinically relevant methicillin-resistant (MRSA), and .

Citing Articles

Coumarin-transition metal complexes with biological activity: current trends and perspectives.

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PMID: 38410816 PMC: 10895002. DOI: 10.3389/fchem.2024.1342772.

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