Coumarin-transition Metal Complexes with Biological Activity: Current Trends and Perspectives

Overview

Journal Front Chem

Specialty Chemistry

Date 2024 Feb 27

PMID 38410816

Authors

Lozan T Todorov

Irena P Kostova

Affiliations

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Abstract

Coumarin (2H-1-benzopyran-2-one) presents the fundamental structure of an enormous class of biologically active compounds of natural, semi-synthetic, and synthetic origin. Extensive efforts are continually being put into the research and development of coumarin derivatives with medicinal properties by the broad scientific community. Transition metal coordination compounds with potential biological activity are a "hot topic" in the modern search for novel drugs. Complexation with transition metals can enhance the physiological effect of a molecule, modify its safety profile, and even imbue it with novel attributes of interest in the fields of medicine and pharmacy. The present review aims to inform the reader of the latest developments in the search for coumarin transition metal complexes with biological activity, their potential applications, and structure-activity relationships, where such can be elucidated. Each section of the present review addresses a certain kind of biological activity (antiproliferative, antioxidant, antimicrobial, etc.), explores the most recent discoveries in the field, and, at the same time, tries to offer useful perspectives for potential future investigations.

Citing Articles

Elucidating the Mechanism of Coumarin Homodimerization Using 3-Acetylcoumarin Derivatives.

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PMID: 39942755 PMC: 11820059. DOI: 10.3390/molecules30030651.

The Phosphorus-Iron Nexus: Decoding the Nutrients Interaction in Soil and Plant.

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