Metagenomic Next-Generation Sequencing Contributes to the Diagnosis of Pneumonia Caused by in a Male Patient: Case Report and Literature Review

Overview

Journal Infect Drug Resist

Publisher Dove Medical Press

Date 2023 Jun 9

PMID 37293537

Authors

Fan Gong

Zhikui Chen

Jianyuan Chang

Jinlong Liu

Xiaobin Wang

Weisong Mo

Mengqin Tan

Tao Jiang

Affiliations

Soon will be listed here.

Abstract

Background: is generally considered as the main cause of ruminants abortion, but it rarely causes human infection resulting in abortion or pneumonia.

Case Presentation: We report a case of male patient with pneumonia caused by . Results of next generation sequencing (NGS) in the bronchoalveolar lavage fluid (BALF) indicated infection. The patient was treated with intravenous infusion of doxycycline. The clinical symptoms of this patient were ameliorated significantly, and all these improvement were indicated by laboratory parameters significantly. Shown as chest computed tomography (CT), most of the inflammation had been absorbed after doxycycline treatment.

Conclusion: mainly infects ruminants and occasionally humans. NGS has its own advantages of rapidity, sensitivity and specificity in detecting . Doxycycline exhibits a great therapeutic effect on pneumonia caused by .

Citing Articles

Chlamydiosis in Animals.

Caspe S, Hill H Animals (Basel). 2024; 14(21).

PMID: 39518853 PMC: 11545194. DOI: 10.3390/ani14213130.

Atypical pneumonia caused by Chlamydia abortus in HIV patient: a case report.

Wang M, Zhang B, Wan H, Yu L BMC Pulm Med. 2024; 24(1):479.

PMID: 39334069 PMC: 11438369. DOI: 10.1186/s12890-024-03295-0.

A Case Study of Severe Pneumonia Caused by mixed Infection of and in a Female Patient.

Ye D, Li Y, Yan K, Peng W Infect Drug Resist. 2024; 17:3561-3567.

PMID: 39161470 PMC: 11330852. DOI: 10.2147/IDR.S469837.

Clinical diagnosis and treatment of seven patients diagnosed pneumonia caused by : a case series report.

Wen Y, Du Y, Shi X, Zeng Z Front Med (Lausanne). 2024; 11:1406737.

PMID: 38919935 PMC: 11196609. DOI: 10.3389/fmed.2024.1406737.

References

Roberts W, Grist N, Giroud P . Human abortion associated with infection by ovine abortion agent. Br Med J. 1967; 4(5570):37. PMC: 1748820. DOI: 10.1136/bmj.4.5570.37. View

Zhang H, Zhan D, Chen D, Huang W, Yu M, Li Q . Next-generation sequencing diagnosis of severe pneumonia from fulminant psittacosis with multiple organ failure: a case report and literature review. Ann Transl Med. 2020; 8(6):401. PMC: 7186658. DOI: 10.21037/atm.2020.03.17. View

Meijer A, Brandenburg A, de Vries J, Beentjes J, Roholl P, Dercksen D . Chlamydophila abortus infection in a pregnant woman associated with indirect contact with infected goats. Eur J Clin Microbiol Infect Dis. 2004; 23(6):487-90. DOI: 10.1007/s10096-004-1139-z. View

Miao Q, Ma Y, Wang Q, Pan J, Zhang Y, Jin W . Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing When Applied to Clinical Practice. Clin Infect Dis. 2018; 67(suppl_2):S231-S240. DOI: 10.1093/cid/ciy693. View

Wang S, Chen Y, Wang D, Wu Y, Zhao D, Zhang J . The Feasibility of Metagenomic Next-Generation Sequencing to Identify Pathogens Causing Tuberculous Meningitis in Cerebrospinal Fluid. Front Microbiol. 2019; 10:1993. PMC: 6733977. DOI: 10.3389/fmicb.2019.01993. View

Pichon N, Guindre L, Laroucau K, Cantaloube M, Nallatamby A, Parreau S . Chlamydia abortus in Pregnant Woman with Acute Respiratory Distress Syndrome. Emerg Infect Dis. 2020; 26(3):628-629. PMC: 7045842. DOI: 10.3201/eid2603.191417. View

Szymanska-Czerwinska M, Mitura A, Zareba K, Schnee C, Koncicki A, Niemczuk K . Poultry in Poland as Carrier. J Vet Res. 2018; 61(4):411-419. PMC: 5937338. DOI: 10.1515/jvetres-2017-0072. View

Zhu C, Lv M, Huang J, Zhang C, Xie L, Gao T . Bloodstream infection and pneumonia caused by Chlamydia abortus infection in China: a case report. BMC Infect Dis. 2022; 22(1):181. PMC: 8867867. DOI: 10.1186/s12879-022-07158-z. View

Teankum K, Pospischil A, Janett F, Brugnera E, Hoelzle L, Hoelzle K . Prevalence of chlamydiae in semen and genital tracts of bulls, rams and bucks. Theriogenology. 2006; 67(2):303-10. DOI: 10.1016/j.theriogenology.2006.07.012. View

10.

Chen Z, Cheng H, Cai Z, Wei Q, Li J, Liang J . Identification of Microbiome Etiology Associated With Drug Resistance in Pleural Empyema. Front Cell Infect Microbiol. 2021; 11:637018. PMC: 8008065. DOI: 10.3389/fcimb.2021.637018. View

11.

Walder G, Hotzel H, Brezinka C, Gritsch W, Tauber R, Wurzner R . An unusual cause of sepsis during pregnancy: recognizing infection with chlamydophila abortus. Obstet Gynecol. 2005; 106(5 Pt 2):1215-7. DOI: 10.1097/01.AOG.0000161060.69470.9c. View

12.

Campos-Hernandez E, Vazquez-Chagoyan J, Salem A, Saltijeral-Oaxaca J, Escalante-Ochoa C, Lopez-Heydeck S . Prevalence and molecular identification of Chlamydia abortus in commercial dairy goat farms in a hot region in Mexico. Trop Anim Health Prod. 2014; 46(6):919-24. DOI: 10.1007/s11250-014-0585-6. View

13.

Walder G, Meusburger H, Hotzel H, Oehme A, Neunteufel W, Dierich M . Chlamydophila abortus pelvic inflammatory disease. Emerg Infect Dis. 2004; 9(12):1642-4. PMC: 3034334. DOI: 10.3201/eid0912.020566. View

14.

Cheong H, Lee C, Cheok Y, Tan G, Looi C, Wong W . : Diseases in Primary Hosts and Zoonosis. Microorganisms. 2019; 7(5). PMC: 6560403. DOI: 10.3390/microorganisms7050146. View

15.

Ortega N, Caro M, Gallego M, Murcia-Belmonte A, Alvarez D, Del Rio L . Isolation of Chlamydia abortus from a laboratory worker diagnosed with atypical pneumonia. Ir Vet J. 2016; 69:8. PMC: 4955219. DOI: 10.1186/s13620-016-0067-4. View

16.

Salinas J, Ortega N, Borge C, Rangel M, Carbonero A, Perea A . Abortion associated with Chlamydia abortus in extensively reared Iberian sows. Vet J. 2012; 194(1):133-4. DOI: 10.1016/j.tvjl.2012.03.002. View

17.

Li Z, Cao X, Fu B, Chao Y, Cai J, Zhou J . Identification and characterization of Chlamydia abortus isolates from yaks in Qinghai, China. Biomed Res Int. 2015; 2015:658519. PMC: 4427853. DOI: 10.1155/2015/658519. View

18.

Donati M, Pollini G, Sparacino M, Fortugno M, LAGHI E, Cevenini R . Comparative in vitro activity of garenoxacin against Chlamydia spp. J Antimicrob Chemother. 2002; 50(3):407-10. DOI: 10.1093/jac/dkf145. View

19.

Pospischil A, Thoma R, Hilbe M, Grest P, Zimmermann D, Gebbers J . [Abortion in humans caused by Chlamydophila abortus (Chlamydia psittaci serovar 1)]. Schweiz Arch Tierheilkd. 2003; 144(9):463-6. DOI: 10.1024/0036-7281.144.9.463. View

20.

Hyde S, Benirschke K . Gestational psittacosis: case report and literature review. Mod Pathol. 1997; 10(6):602-7. View