Bloodstream Infection and Pneumonia Caused by Chlamydia Abortus Infection in China: a Case Report

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2022 Feb 24

PMID 35197012

Authors

Changjun Zhu

Minjie Lv

Jianling Huang

Changwen Zhang

Lixu Xie

TianMing Gao

Bo Han

Wenjing Wang

Ganzhu Feng

Affiliations

Soon will be listed here.

Abstract

Background: Chlamydia abortus is generally considered to cause abortion, stillbirth, and gestational sepsis in pregnant women, but it's rare in bloodstream infection and pneumonia.

Case Presentation: We present details of a patient with bloodstream infection and pneumonia caused by Chlamydia abortus. Both blood next-generation sequencing (NGS) and sputum NGS indicate Chlamydia abortus infection. The patient received intravenous infusion of piperacillin sodium and tazobactam sodium (4.5 g/8 h) and moxifloxacin (0.4 g/d) and oral oseltamivir (75 mg/day). Within one month of follow-up, the patient's clinical symptoms were significantly improved, and all laboratory parameters showed no marked abnormality. However, chest computer tomography (CT) showed the inflammation wasn't completely absorbed. And we are still following up.

Conclusions: Chlamydia abortus can cause pneumonia in humans. NGS has the particular advantage of quickly and accurately identifying the infection of such rare pathogens. Pneumonia is generally not life-threatening, and has a good prognosis with appropriate treatment. However, Chlamydia infection can lead to serious visceral complications which clinicians should pay attention to.

Citing Articles

Atypical pneumonia caused by Chlamydia abortus in HIV patient: a case report.

Wang M, Zhang B, Wan H, Yu L BMC Pulm Med. 2024; 24(1):479.

PMID: 39334069 PMC: 11438369. DOI: 10.1186/s12890-024-03295-0.

Prone positioning ventilation treatment rescuing a patient with chlamydia abortus-induced ARDS diagnosed by next generation sequencing: a case report.

Chen Y, Lan P, Liu L, Zhou K Front Med (Lausanne). 2024; 11:1428300.

PMID: 39328319 PMC: 11424430. DOI: 10.3389/fmed.2024.1428300.

A Case Study of Severe Pneumonia Caused by mixed Infection of and in a Female Patient.

Ye D, Li Y, Yan K, Peng W Infect Drug Resist. 2024; 17:3561-3567.

PMID: 39161470 PMC: 11330852. DOI: 10.2147/IDR.S469837.

Severe community-acquired pneumonia caused by in China: a case report.

Yang Q, Shu C Front Med (Lausanne). 2024; 11:1426577.

PMID: 39104862 PMC: 11298455. DOI: 10.3389/fmed.2024.1426577.

Clinical diagnosis and treatment of seven patients diagnosed pneumonia caused by : a case series report.

Wen Y, Du Y, Shi X, Zeng Z Front Med (Lausanne). 2024; 11:1406737.

PMID: 38919935 PMC: 11196609. DOI: 10.3389/fmed.2024.1406737.

References

Roberts W, Grist N, Giroud P . Human abortion associated with infection by ovine abortion agent. Br Med J. 1967; 4(5570):37. PMC: 1748820. DOI: 10.1136/bmj.4.5570.37. View

Longbottom D, Coulter L . Animal chlamydioses and zoonotic implications. J Comp Pathol. 2003; 128(4):217-44. DOI: 10.1053/jcpa.2002.0629. View

Steuernagel B, Taudien S, Gundlach H, Seidel M, Ariyadasa R, Schulte D . De novo 454 sequencing of barcoded BAC pools for comprehensive gene survey and genome analysis in the complex genome of barley. BMC Genomics. 2009; 10:547. PMC: 2784808. DOI: 10.1186/1471-2164-10-547. View

Kohlhoff S, Hammerschlag M . Treatment of Chlamydial infections: 2014 update. Expert Opin Pharmacother. 2015; 16(2):205-12. DOI: 10.1517/14656566.2015.999041. View

Ortega N, Caro M, Gallego M, Murcia-Belmonte A, Alvarez D, Del Rio L . Isolation of Chlamydia abortus from a laboratory worker diagnosed with atypical pneumonia. Ir Vet J. 2016; 69:8. PMC: 4955219. DOI: 10.1186/s13620-016-0067-4. View

De Barbeyrac B, Bebear C . [Chlamydial pathogenesis: diagnostic and therapeutic consequences]. Arch Pediatr. 2005; 12 Suppl 1:S26-31. DOI: 10.1016/s0929-693x(05)80007-7. View

Miao Q, Ma Y, Wang Q, Pan J, Zhang Y, Jin W . Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing When Applied to Clinical Practice. Clin Infect Dis. 2018; 67(suppl_2):S231-S240. DOI: 10.1093/cid/ciy693. View

Pichon N, Guindre L, Laroucau K, Cantaloube M, Nallatamby A, Parreau S . Chlamydia abortus in Pregnant Woman with Acute Respiratory Distress Syndrome. Emerg Infect Dis. 2020; 26(3):628-629. PMC: 7045842. DOI: 10.3201/eid2603.191417. View

Bommana S, Polkinghorne A . Mini Review: Antimicrobial Control of Chlamydial Infections in Animals: Current Practices and Issues. Front Microbiol. 2019; 10:113. PMC: 6369208. DOI: 10.3389/fmicb.2019.00113. View

10.

Szymanska-Czerwinska M, Mitura A, Zareba K, Schnee C, Koncicki A, Niemczuk K . Poultry in Poland as Carrier. J Vet Res. 2018; 61(4):411-419. PMC: 5937338. DOI: 10.1515/jvetres-2017-0072. View

11.

Lecuit M, Eloit M . The potential of whole genome NGS for infectious disease diagnosis. Expert Rev Mol Diagn. 2015; 15(12):1517-9. DOI: 10.1586/14737159.2015.1111140. View

12.

Rohde G, Straube E, Essig A, Reinhold P, Sachse K . Chlamydial zoonoses. Dtsch Arztebl Int. 2010; 107(10):174-80. PMC: 2847324. DOI: 10.3238/arztebl.2010.0174. View

13.

Ruhl S, Goy G, Casson N, Thoma R, Pospischil A, Greub G . Parachlamydia acanthamoebae infection and abortion in small ruminants. Emerg Infect Dis. 2008; 14(12):1966-8. PMC: 2634627. DOI: 10.3201/eid1412.080582. View

14.

Li Z, Liu P, Cao X, Lou Z, Zareba-Marchewka K, Szymanska-Czerwinska M . First Report of in Farmed Fur Animals. Biomed Res Int. 2019; 2018:4289648. PMC: 6287152. DOI: 10.1155/2018/4289648. View

15.

Teankum K, Pospischil A, Janett F, Brugnera E, Hoelzle L, Hoelzle K . Prevalence of chlamydiae in semen and genital tracts of bulls, rams and bucks. Theriogenology. 2006; 67(2):303-10. DOI: 10.1016/j.theriogenology.2006.07.012. View

16.

Wilson M, Naccache S, Samayoa E, Biagtan M, Bashir H, Yu G . Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med. 2014; 370(25):2408-17. PMC: 4134948. DOI: 10.1056/NEJMoa1401268. View

17.

Pospischil A, Thoma R, Hilbe M, Grest P, Zimmermann D, Gebbers J . [Abortion in humans caused by Chlamydophila abortus (Chlamydia psittaci serovar 1)]. Schweiz Arch Tierheilkd. 2003; 144(9):463-6. DOI: 10.1024/0036-7281.144.9.463. View

18.

Walder G, Hotzel H, Brezinka C, Gritsch W, Tauber R, Wurzner R . An unusual cause of sepsis during pregnancy: recognizing infection with chlamydophila abortus. Obstet Gynecol. 2005; 106(5 Pt 2):1215-7. DOI: 10.1097/01.AOG.0000161060.69470.9c. View

19.

McCombie W, McPherson J, Mardis E . Next-Generation Sequencing Technologies. Cold Spring Harb Perspect Med. 2018; 9(11). PMC: 6824406. DOI: 10.1101/cshperspect.a036798. View

20.

Campos-Hernandez E, Vazquez-Chagoyan J, Salem A, Saltijeral-Oaxaca J, Escalante-Ochoa C, Lopez-Heydeck S . Prevalence and molecular identification of Chlamydia abortus in commercial dairy goat farms in a hot region in Mexico. Trop Anim Health Prod. 2014; 46(6):919-24. DOI: 10.1007/s11250-014-0585-6. View