Jooman Park
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Explore the profile of Jooman Park including associated specialties, affiliations and a list of published articles.
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12
Citations
69
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Recent Articles
1.
Yuan Y, Hu R, Park J, Xiong S, Wang Z, Qian Y, et al.
Sci Adv
. 2024 Jun;
10(26):eadn5229.
PMID: 38924414
There is a regional preference around lymph nodes (LNs) for adipose beiging. Here, we show that local LN removal within inguinal white adipose tissue (iWAT) greatly impairs cold-induced beiging, and...
2.
Park J, Hu R, Qian Y, Xiong S, El-Sabbagh A, Ibrahim M, et al.
Nat Aging
. 2024 Jun;
4(6):839-853.
PMID: 38858606
Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that they offer are compromised with aging. Here we show that treating mice...
3.
The Notch-PDGFRβ axis suppresses brown adipocyte progenitor differentiation in early post-natal mice
Shi Z, Xiong S, Hu R, Wang Z, Park J, Qian Y, et al.
Dev Cell
. 2024 Apr;
59(10):1233-1251.e5.
PMID: 38569546
De novo brown adipogenesis holds potential in combating the epidemics of obesity and diabetes. However, the identity of brown adipocyte progenitor cells (APCs) and their regulation have not been extensively...
4.
Munoz M, Solis C, McCann M, Park J, Rafael-Clyke K, Chowdhury S, et al.
Mol Cell Biochem
. 2024 Mar;
480(1):249-263.
PMID: 38430300
While P21-activated kinase-1 (PAK1) has been extensively studied in relation to cardiovascular health and glucose metabolism, its roles within adipose tissue and cardiometabolic diseases are less understood. In this study,...
5.
Song Q, Hwang C, Li Y, Wang J, Park J, Lee S, et al.
Metabolism
. 2023 Nov;
151:155740.
PMID: 37995805
Background & Aims: Dysbiosis contributes to alcohol-associated liver disease (ALD); however, the precise mechanisms remain elusive. Given the critical role of the gut microbiota in ammonia production, we herein aim...
6.
Park J, Hu R, Xiong S, Qian Y, El-Sabbagh A, Ibrahim M, et al.
bioRxiv
. 2023 Sep;
PMID: 37693431
Highlights: Estrogen restores beige adipocyte failure along with improved energy metabolism in old mice.Estrogen enhances the thermogenic gene program by mitigating age-induced ER stress.Estrogen enhances the beige adipogenesis derived from...
7.
Shi Z, Xiong S, Hu R, Wang Z, Park J, Qian Y, et al.
bioRxiv
. 2023 Jun;
PMID: 37293108
Highlights: PDGFRβ+ pericytes act as an essential developmental brown APC.TBX18+ pericytes contribute to brown adipogenesis in a depot-specific manner.Inhibiting Notch-Pdgfrβ axis promotes brown APC adipogenesis.Enhanced postnatal brown adipogenesis improves metabolic...
8.
Wu R, Park J, Qian Y, Shi Z, Hu R, Yuan Y, et al.
Nat Commun
. 2023 May;
14(1):2731.
PMID: 37169793
A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes. However, beige adipocytes quickly transition into white adipocytes upon removing stimuli. Here, we define the critical role...
9.
Song Q, Chen Y, Ding Q, Griffiths A, Liu L, Park J, et al.
Hepatol Commun
. 2023 Feb;
7(3):e0059.
PMID: 36757400
Background: Adipose tissue thermogenic activities use fatty acids from lipolysis for heat generation. Therefore, a tight coupling between lipolysis and thermogenesis is physiologically imperative in maintaining not only body temperature...
10.
Griffiths A, Wang J, Song Q, Iyamu I, Liu L, Park J, et al.
Am J Physiol Cell Physiol
. 2021 Aug;
321(3):C585-C595.
PMID: 34378991
Defined as the dysfunction and/or cell death caused by toxic lipids accumulation in hepatocytes, hepatic lipotoxicity plays a pathological role in nonalcoholic fatty liver disease. The cellular and molecular mechanisms...