Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 As a Driver of Gastric Differentiation and Indolent Biological Potential

Overview

Journal Cancer Discov

Specialty Oncology

Date 2023 Jun 7

PMID 37285225

Authors

Marta Sans

Yuki Makino

Jimin Min

Kimal I Rajapakshe

Michele Yip-Schneider

C Max Schmidt

Mark W Hurd

Jared K Burks

Javier A Gomez

Fredrik I Thege

Johannes F Fahrmann

Robert A Wolff

Michael P Kim

Paola A Guerrero

Anirban Maitra

Affiliations

Soon will be listed here.

Abstract

Significance: Identification of the molecular features driving IPMN development and differentiation is critical to prevent cancer progression and enhance risk stratification. We used spatial profiling to characterize the epithelium and microenvironment of IPMN, which revealed a previously unknown link between NKX6-2 and gastric differentiation, the latter associated with indolent biological potential. See related commentary by Ben-Shmuel and Scherz-Shouval, p. 1768. This article is highlighted in the In This Issue feature, p. 1749.

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