System-level Immune Monitoring Reveals New Pathophysiological Features in Hepatitis-associated Aplastic Anemia

Overview

Journal Blood Adv

Specialty Hematology

Date 2023 Jun 2

PMID 37267438

Authors

Cecile Braudeau

Laurence Delbos

Marie-Laure Couec

Gwenvael Danic

Justine Chevreuil

Camille Lecuroux

Audrey Grain

Marion Eveillard

Fanny Rialland

Flore Sicre de Fontbrune

Gaelle Beriou

Nicolas Degauque

David Michonneau

Regis Josien

Regis Peffault de Latour

Caroline Thomas

Jerome C Martin

Affiliations

Soon will be listed here.

Citing Articles

Modified Delphi panel consensus recommendations for management of severe aplastic anemia.

Babushok D, DeZern A, de Castro C, Rogers Z, Beenhouwer D, Broder M Blood Adv. 2024; 8(15):3946-3960.

PMID: 38669341 PMC: 11331724. DOI: 10.1182/bloodadvances.2023011642.

References

Kaplanski G . Interleukin-18: Biological properties and role in disease pathogenesis. Immunol Rev. 2017; 281(1):138-153. PMC: 7165732. DOI: 10.1111/imr.12616. View

Hayday A . γδ T Cell Update: Adaptate Orchestrators of Immune Surveillance. J Immunol. 2019; 203(2):311-320. DOI: 10.4049/jimmunol.1800934. View

Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M . The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004; 25(12):677-86. DOI: 10.1016/j.it.2004.09.015. View

Seyfried A, McCabe A, Smith J, Calvi L, MacNamara K . CCR5 maintains macrophages in the bone marrow and drives hematopoietic failure in a mouse model of severe aplastic anemia. Leukemia. 2021; 35(11):3139-3151. PMC: 8849945. DOI: 10.1038/s41375-021-01219-z. View

Davey M, Willcox C, Baker A, Hunter S, Willcox B . Recasting Human Vδ1 Lymphocytes in an Adaptive Role. Trends Immunol. 2018; 39(6):446-459. PMC: 5980997. DOI: 10.1016/j.it.2018.03.003. View

Hunter S, Willcox C, Davey M, Kasatskaya S, Jeffery H, Chudakov D . Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations. J Hepatol. 2018; 69(3):654-665. PMC: 6089840. DOI: 10.1016/j.jhep.2018.05.007. View

Ding Y, Zhou L, Xia Y, Wang W, Wang Y, Li L . Reference values for peripheral blood lymphocyte subsets of healthy children in China. J Allergy Clin Immunol. 2018; 142(3):970-973.e8. DOI: 10.1016/j.jaci.2018.04.022. View

Braudeau C, Salabert-Le Guen N, Chevreuil J, Rimbert M, Martin J, Josien R . An easy and reliable whole blood freezing method for flow cytometry immuno-phenotyping and functional analyses. Cytometry B Clin Cytom. 2021; 100(6):652-665. DOI: 10.1002/cyto.b.21994. View

Kapellos T, Bonaguro L, Gemund I, Reusch N, Saglam A, Hinkley E . Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases. Front Immunol. 2019; 10:2035. PMC: 6728754. DOI: 10.3389/fimmu.2019.02035. View

10.

Morbach H, Eichhorn E, Liese J, Girschick H . Reference values for B cell subpopulations from infancy to adulthood. Clin Exp Immunol. 2010; 162(2):271-9. PMC: 2996594. DOI: 10.1111/j.1365-2249.2010.04206.x. View

11.

Marsh J, Ball S, Darbyshire P, Gordon-Smith E, Keidan A, Martin A . Guidelines for the diagnosis and management of acquired aplastic anaemia. Br J Haematol. 2003; 123(5):782-801. DOI: 10.1046/j.1365-2141.2003.04721.x. View

12.

Lu J, Basu A, Melenhorst J, Young N, Brown K . Analysis of T-cell repertoire in hepatitis-associated aplastic anemia. Blood. 2004; 103(12):4588-93. DOI: 10.1182/blood-2003-11-3959. View

13.

Young N . Aplastic Anemia. N Engl J Med. 2018; 379(17):1643-1656. PMC: 6467577. DOI: 10.1056/NEJMra1413485. View

14.

Luster A, Ravetch J . Biochemical characterization of a gamma interferon-inducible cytokine (IP-10). J Exp Med. 1987; 166(4):1084-97. PMC: 2188708. DOI: 10.1084/jem.166.4.1084. View

15.

Brown K, Tisdale J, Barrett A, Dunbar C, Young N . Hepatitis-associated aplastic anemia. N Engl J Med. 1997; 336(15):1059-64. DOI: 10.1056/NEJM199704103361504. View

16.

von Borstel A, Chevour P, Arsovski D, Krol J, Howson L, Berry A . Repeated infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire. Sci Transl Med. 2021; 13(622):eabe7430. PMC: 9291638. DOI: 10.1126/scitranslmed.abe7430. View

17.

Gonzalez-Casas R, Garcia-Buey L, Jones E, Gisbert J, Moreno-Otero R . Systematic review: hepatitis-associated aplastic anaemia--a syndrome associated with abnormal immunological function. Aliment Pharmacol Ther. 2009; 30(5):436-43. DOI: 10.1111/j.1365-2036.2009.04060.x. View

18.

Dufour J, Dziejman M, Liu M, Leung J, Lane T, Luster A . IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol. 2002; 168(7):3195-204. DOI: 10.4049/jimmunol.168.7.3195. View

19.

Chow A, Lucas D, Hidalgo A, Mendez-Ferrer S, Hashimoto D, Scheiermann C . Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med. 2011; 208(2):261-71. PMC: 3039855. DOI: 10.1084/jem.20101688. View

20.

Sun W, Wu Z, Lin Z, Hollinger M, Chen J, Feng X . Macrophage TNF-α licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia. Blood. 2018; 132(26):2730-2743. PMC: 6307988. DOI: 10.1182/blood-2018-05-844928. View