Recasting Human Vδ1 Lymphocytes in an Adaptive Role

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2018 Apr 23

PMID 29680462

Citations 53

Authors

Martin S Davey

Carrie R Willcox

Alfie T Baker

Stuart Hunter

Benjamin E Willcox

Affiliations

Soon will be listed here.

Abstract

γδ T cells are unconventional lymphocytes commonly described as 'innate-like' in function, which can respond in both a T cell receptor (TCR)-independent and also major histocompatibility complex (MHC)-unrestricted TCR-dependent manner. While the relative importance of TCR recognition had remained unclear, recent studies revealed that human Vδ1 T cells display unexpected parallels with adaptive αβ T cells. Vδ1 T cells undergo profound and highly focussed clonal expansion from an initially diverse and private TCR repertoire, most likely in response to specific immune challenges. Concomitantly, they differentiate from a Vδ1 T cell naïve (T) to a Vδ1 T cell effector (T) phenotype, marked by the downregulation of lymphoid homing receptors and upregulation of peripheral homing receptors and effector markers. This suggests that an adaptive paradigm applies to Vδ1 T cells, likely involving TCR-dependent but MHC-unrestricted responses to microbial and non-microbial challenges.

Citing Articles

Characterization of the Bone Marrow Lymphoid Microenvironment and Discovery of Prognostic Immune-Related Factors in Acute Myeloid Leukemia.

Kim Y, Kwag D, Kim B, Son H, Park S, Kim H Int J Mol Sci. 2024; 25(23).

PMID: 39684749 PMC: 11641137. DOI: 10.3390/ijms252313039.

T cell receptor-centric perspective to multimodal single-cell data analysis.

Mullan K, Ha M, Valkiers S, de Vrij N, Ogunjimi B, Laukens K Sci Adv. 2024; 10(48):eadr3196.

PMID: 39612336 PMC: 11606500. DOI: 10.1126/sciadv.adr3196.

Dual role of circulating and mucosal Vδ1 T cells in the control of and contribution to persistent HIV-1 infection.

Mann B, Sanz M, Clohosey M, Langlands K, Chitrakar A, Moreno C Res Sq. 2024; .

PMID: 39149467 PMC: 11326412. DOI: 10.21203/rs.3.rs-4784403/v1.

Gamma delta (γδ) T cells in the female reproductive tract: active participants or indifferent bystanders in reproductive success?.

Foyle K, Robertson S Discov Immunol. 2024; 3(1):kyae004.

PMID: 38863792 PMC: 11165432. DOI: 10.1093/discim/kyae004.

Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span.

Gray J, Caron D, Wells S, Guyer R, Szabo P, Rainbow D Sci Immunol. 2024; 9(96):eadn3954.

PMID: 38848342 PMC: 11425769. DOI: 10.1126/sciimmunol.adn3954.

References

McVay L, Carding S . Extrathymic origin of human gamma delta T cells during fetal development. J Immunol. 1996; 157(7):2873-82. View

Goshorn S, Retzel E, Jemmerson R . Common structural features among monoclonal antibodies binding the same antigenic region of cytochrome c. J Biol Chem. 1991; 266(4):2134-42. View

Rhodes D, Reith W, Trowsdale J . Regulation of Immunity by Butyrophilins. Annu Rev Immunol. 2016; 34:151-72. DOI: 10.1146/annurev-immunol-041015-055435. View

Yaari G, Kleinstein S . Practical guidelines for B-cell receptor repertoire sequencing analysis. Genome Med. 2015; 7:121. PMC: 4654805. DOI: 10.1186/s13073-015-0243-2. View

Bolotin D, Poslavsky S, Mitrophanov I, Shugay M, Mamedov I, Putintseva E . MiXCR: software for comprehensive adaptive immunity profiling. Nat Methods. 2015; 12(5):380-1. DOI: 10.1038/nmeth.3364. View

Burnet F . A modification of Jerne's theory of antibody production using the concept of clonal selection. CA Cancer J Clin. 1976; 26(2):119-21. DOI: 10.3322/canjclin.26.2.119. View

Goodier M, Jonjic S, Riley E, Juranic Lisnic V . CMV and natural killer cells: shaping the response to vaccination. Eur J Immunol. 2017; 48(1):50-65. DOI: 10.1002/eji.201646762. View

Luoma A, Castro C, Mayassi T, Bembinster L, Bai L, Picard D . Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells. Immunity. 2013; 39(6):1032-42. PMC: 3875342. DOI: 10.1016/j.immuni.2013.11.001. View

Vantourout P, Hayday A . Six-of-the-best: unique contributions of γδ T cells to immunology. Nat Rev Immunol. 2013; 13(2):88-100. PMC: 3951794. DOI: 10.1038/nri3384. View

10.

Guo X, Dash P, Calverley M, Tomchuck S, Dallas M, Thomas P . Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis. Mol Ther Methods Clin Dev. 2016; 3:15054. PMC: 4729322. DOI: 10.1038/mtm.2015.54. View

11.

Dellabona P, Padovan E, Casorati G, Brockhaus M, Lanzavecchia A . An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J Exp Med. 1994; 180(3):1171-6. PMC: 2191638. DOI: 10.1084/jem.180.3.1171. View

12.

Deusch K, Luling F, Reich K, Classen M, Wagner H, Pfeffer K . A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur J Immunol. 1991; 21(4):1053-9. DOI: 10.1002/eji.1830210429. View

13.

Janeway Jr C, Jones B, Hayday A . Specificity and function of T cells bearing gamma delta receptors. Immunol Today. 1988; 9(3):73-6. DOI: 10.1016/0167-5699(88)91267-4. View

14.

Lafarge X, Merville P, Cazin M, Berge F, Potaux L, Moreau J . Cytomegalovirus infection in transplant recipients resolves when circulating gammadelta T lymphocytes expand, suggesting a protective antiviral role. J Infect Dis. 2001; 184(5):533-41. DOI: 10.1086/322843. View

15.

Nazarov V, Pogorelyy M, Komech E, Zvyagin I, Bolotin D, Shugay M . tcR: an R package for T cell receptor repertoire advanced data analysis. BMC Bioinformatics. 2015; 16:175. PMC: 4445501. DOI: 10.1186/s12859-015-0613-1. View

16.

Khairallah C, Netzer S, Villacreces A, Juzan M, Rousseau B, Dulanto S . γδ T cells confer protection against murine cytomegalovirus (MCMV). PLoS Pathog. 2015; 11(3):e1004702. PMC: 4352080. DOI: 10.1371/journal.ppat.1004702. View

17.

Morita C, Parker C, Brenner M, Band H . TCR usage and functional capabilities of human gamma delta T cells at birth. J Immunol. 1994; 153(9):3979-88. View

18.

McVay L, Carding S, Bottomly K, Hayday A . Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny. EMBO J. 1991; 10(1):83-91. PMC: 452615. DOI: 10.1002/j.1460-2075.1991.tb07923.x. View

19.

Asarnow D, Kuziel W, Bonyhadi M, Tigelaar R, Tucker P, Allison J . Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell. 1988; 55(5):837-47. DOI: 10.1016/0092-8674(88)90139-0. View

20.

Wiertz E, Hill A, Tortorella D, Ploegh H . Cytomegaloviruses use multiple mechanisms to elude the host immune response. Immunol Lett. 1997; 57(1-3):213-6. DOI: 10.1016/s0165-2478(97)00073-4. View