Mapping the Nanotechnology Patent Landscape in the Field of Cancer

Overview

Journal Recent Pat Nanotechnol

Publisher Bentham Science Publishers

Specialty Biotechnology

Date 2023 Jun 1

PMID 37259209

Authors

Haoyu Sun

Tong Wu

Xinrui Liu

Huanzhang Xia

Hongmei Yuan

Affiliations

Soon will be listed here.

Abstract

Background: Currently, cancer is still a significant disease that seriously endangers human health. Therefore, advanced diagnostic technology and treatment protocols are urgently needed. The rapid development of nanotechnology is expected to provide new ideas for cancer diagnosis and treatment.

Objective: The research aims to comprehensively demonstrate the hotspots of nanotechnology applications in cancer.

Methods: In this study, an International Patent Classification codes co-occurrence network is constructed to visualize the technology landscape by simultaneously locating and ranking technologies that play an integral role in nanotechnology diffusion and bridging in the field of cancer. In addition, community identification and topic modeling highlight the latent topics in patent documents.

Results: The visualization results of the patent network yield five main clusters: Cluster 0 is a nanoparticle composition delivery system with liposomes as the primary carrier. Cluster 1 is mainly represented by nano-immunotherapy with immune checkpoint inhibitors. Cluster 2 is nano phototherapy based on photodynamic therapy and photothermal therapy. Cluster 3 is diagnostic imaging involving nanotechnology. Cluster 4 is a drug delivery system with nanovesicles and albumin nanoparticles as carriers.

Conclusion: It was found that carriers represented by liposomes, vesicles, and albumin nanoparticles are essential nanomaterials in the current anticancer drug delivery systems. Integrating next-generation immunosuppressants and nanotechnology will become an important development direction for future immunotherapy. Organic/inorganic nanomaterials are pivotal in cancer imaging diagnosis and phototherapy.

Citing Articles

Nano-energy interference: A novel strategy for blunting tumor adaptation and metastasis.

Teng F, Fu D, Shi C, Xiong A, Yang M, Su C Mater Today Bio. 2024; 25:100984.

PMID: 38356962 PMC: 10865032. DOI: 10.1016/j.mtbio.2024.100984.

References

Zaimy M, Saffarzadeh N, Mohammadi A, Pourghadamyari H, Izadi P, Sarli A . New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles. Cancer Gene Ther. 2017; 24(6):233-243. DOI: 10.1038/cgt.2017.16. View

Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F . The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine. Molecules. 2020; 25(1). PMC: 6982820. DOI: 10.3390/molecules25010112. View

Yin Q, Wang Y, Xiang Y, Xu F . Nanovaccines: Merits, and diverse roles in boosting antitumor immune responses. Hum Vaccin Immunother. 2022; 18(6):2119020. PMC: 9746515. DOI: 10.1080/21645515.2022.2119020. View

Khoobchandani M, Katti K, Raphael Karikachery A, Thipe V, Srisrimal D, Dhurvas Mohandoss D . New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine - Pre-Clinical and Pilot Human Clinical Investigations. Int J Nanomedicine. 2020; 15:181-197. PMC: 6970107. DOI: 10.2147/IJN.S219042. View

Parekh G, Shi Y, Zheng J, Zhang X, Leporatti S . Nano-carriers for targeted delivery and biomedical imaging enhancement. Ther Deliv. 2018; 9(6):451-468. DOI: 10.4155/tde-2018-0013. View

Shi J, Kantoff P, Wooster R, Farokhzad O . Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2016; 17(1):20-37. PMC: 5575742. DOI: 10.1038/nrc.2016.108. View

Ma L, Diao L, Peng Z, Jia Y, Xie H, Li B . Immunotherapy and Prevention of Cancer by Nanovaccines Loaded with Whole-Cell Components of Tumor Tissues or Cells. Adv Mater. 2021; 33(43):e2104849. DOI: 10.1002/adma.202104849. View

Patra J, Das G, Fraceto L, Campos E, Del Pilar Rodriguez-Torres M, Acosta-Torres L . Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018; 16(1):71. PMC: 6145203. DOI: 10.1186/s12951-018-0392-8. View

Silva M, Calado R, Marto J, Bettencourt A, Almeida A, Goncalves L . Chitosan Nanoparticles as a Mucoadhesive Drug Delivery System for Ocular Administration. Mar Drugs. 2017; 15(12). PMC: 5742830. DOI: 10.3390/md15120370. View

10.

Kaur A, Jain K, Mehra N, Jain N . Development and characterization of surface engineered PPI dendrimers for targeted drug delivery. Artif Cells Nanomed Biotechnol. 2016; 45(3):414-425. DOI: 10.3109/21691401.2016.1160912. View

11.

McNamara K, Tofail S . Nanosystems: the use of nanoalloys, metallic, bimetallic, and magnetic nanoparticles in biomedical applications. Phys Chem Chem Phys. 2015; 17(42):27981-95. DOI: 10.1039/c5cp00831j. View

12.

Gomez-Grana S, Perez-Juste J, Herves P . Cyclodextrins and inorganic nanoparticles: Another tale of synergy. Adv Colloid Interface Sci. 2020; 288:102338. DOI: 10.1016/j.cis.2020.102338. View

13.

Chaturvedi V, Singh A, Singh V, Singh M . Cancer Nanotechnology: A New Revolution for Cancer Diagnosis and Therapy. Curr Drug Metab. 2018; 20(6):416-429. DOI: 10.2174/1389200219666180918111528. View

14.

Janse M, Zinkweg D, Larsen O, van de Burgwal L . Innovations in the veterinary intestinal health field: A patent landscape analysis. One Health. 2022; 15:100419. PMC: 9582549. DOI: 10.1016/j.onehlt.2022.100419. View

15.

Jui C, Trappey A, Fu C . Discover Patent Landscape of Two-photon Polymerization Technology for the Production of 3D Nano-structure Using Claim-based Approach. Recent Pat Nanotechnol. 2018; 12(3):218-230. DOI: 10.2174/1872210512666180817121454. View

16.

Pandey P, Dureja H . Recent Patents on Polymeric Nanoparticles for Cancer Therapy. Recent Pat Nanotechnol. 2018; 12(2):155-169. DOI: 10.2174/1872210512666180327120648. View

17.

Li S, Wei X, Li S, Zhu C, Wu C . Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment. Int J Nanomedicine. 2020; 15:9431-9445. PMC: 7701150. DOI: 10.2147/IJN.S266006. View

18.

Bockamp E, Rosigkeit S, Siegl D, Schuppan D . Nano-Enhanced Cancer Immunotherapy: Immunology Encounters Nanotechnology. Cells. 2020; 9(9). PMC: 7565449. DOI: 10.3390/cells9092102. View

19.

Holditch S, Brown C, Lombardi A, Nguyen K, Edelstein C . Recent Advances in Models, Mechanisms, Biomarkers, and Interventions in Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2019; 20(12). PMC: 6627318. DOI: 10.3390/ijms20123011. View

20.

Pardoll D . The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012; 12(4):252-64. PMC: 4856023. DOI: 10.1038/nrc3239. View