Huanzhang Xia
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Explore the profile of Huanzhang Xia including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
140
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Recent Articles
1.
Zhai H, Yang L, Ye Q, Kong Z, Pei J, Ji Y, et al.
Microb Cell Fact
. 2025 Feb;
24(1):49.
PMID: 40016797
Background: Aminoglycoside antibiotics continue to play an indispensable role in clinical antibacterial agents. However, the protection and deprotection procedures in the chemical pathways of semi-synthetic antibiotics are long, atom- and...
2.
Bai Y, Wu X, Shen Y, Wang L, Cheng Z, Sun Y, et al.
Viruses
. 2025 Feb;
17(2).
PMID: 40006992
Norovirus is a major etiological agent of nonbacterial gastroenteritis around the world. Due to its in vitro culture complexity, high genome diversity, and the lack of cross-reactive immunity between genogroups,...
3.
Mou P, Peng Y, Zhang B, Wang P, Ni X, Xia H
Nat Prod Res
. 2024 Nov;
:1-7.
PMID: 39520714
a new benzodioxole derivative 1,3-benzodioxole-2-one-4--methylcarboxylamide (), two new natural products -(aminocarbonyl)-2,3-dimethoxy-benzamide () and 2,3-dimethoxy--methylbenzamide (), along with eight known compounds (-), were isolated from the marine-derived sp. SYPHU 0002. The...
4.
Sun H, Wu T, Liu X, Xia H, Yuan H
Recent Pat Nanotechnol
. 2023 Jun;
18(3):321-334.
PMID: 37259209
Background: Currently, cancer is still a significant disease that seriously endangers human health. Therefore, advanced diagnostic technology and treatment protocols are urgently needed. The rapid development of nanotechnology is expected...
5.
Sun J, Gao H, Yan D, Liu Y, Ni X, Xia H
J Ind Microbiol Biotechnol
. 2022 May;
49(4).
PMID: 35536571
A structurally unique aminoglycoside produced in Streptoalloteichus tenebrarius, Apramycin is used in veterinary medicine or the treatment of Salmonella, Escherichia coli, and Pasteurella multocida infections. Although apramycin was discovered nearly...
6.
Yuan J, Li J, Yang L, Lv Y, Wang C, Jin Z, et al.
Int Immunopharmacol
. 2021 Aug;
99:107982.
PMID: 34333355
Recombinant human thrombopoietin (rhTPO) was approved by the National Medical Products Administration in 2010 for the treatment of thrombocytopenia in patients with immune thrombocytopenic purpura and chemotherapy-induced thrombocytopenia. Nevertheless, no...
7.
Chen G, Wang M, Ni X, Xia H
J Biol Eng
. 2021 May;
15(1):16.
PMID: 34022922
Background: Tetramycin is a 26-member tetraene antibiotic used in agriculture. It has two components, tetramycin A and tetramycin B. Tetramycin B is obtained by the hydroxylation of tetramycin A on...
8.
Zhou S, Chen X, Ni X, Liu Y, Zhang H, Dong M, et al.
Microb Cell Fact
. 2021 Mar;
20(1):65.
PMID: 33750386
Background: The C-3',4'-dideoxygenation structure in gentamicin can prevent deactivation by aminoglycoside 3'-phosphotransferase (APH(3')) in drug-resistant pathogens. However, the enzyme catalyzing the dideoxygenation step in the gentamicin biosynthesis pathway remains unknown....
9.
Chen X, Zhang H, Zhou S, Bi M, Qi S, Gao H, et al.
Microb Cell Fact
. 2020 Mar;
19(1):62.
PMID: 32156271
Background: New semi-synthetic aminoglycoside antibiotics generally use chemical modifications to avoid inactivity from pathogens. One of the most used modifications is 3',4'-di-deoxygenation, which imitates the structure of gentamicin. However, the...
10.
Wu Z, Gao W, Zhou S, Wen Z, Ni X, Xia H
Microbiol Res
. 2017 Jul;
203:40-46.
PMID: 28754206
Gentamicin B and gentamicin C1a are the direct precursor for Isepamicin and Etimicin synthesis, respectively. Although producing strains have been improved for many years, both gentamicin B titer and gentamicin...