Mussel-inspired HA@TA-CS/SA Biomimetic 3D Printed Scaffolds with Antibacterial Activity for Bone Repair

Overview

Journal Front Bioeng Biotechnol

Date 2023 May 25

PMID 37229495

Authors

Cheng Ji

Chengcheng Zhang

Zeya Xu

Yan Chen

Yanming Gan

Minghui Zhou

Lan Li

Qinying Duan

Tingting Huang

Jinxin Lin

Affiliations

Soon will be listed here.

Abstract

Bacterial infection is a major challenge that could threaten the patient's life in repairing bone defects with implant materials. Developing functional scaffolds with an intelligent antibacterial function that can be used for bone repair is very important. We constructed a drug delivery (HA@TA-CS/SA) scaffold with curcumin-loaded dendritic mesoporous organic silica nanoparticles (DMON@Cur) via 3D printing for antibacterial bone repair. Inspired by the adhesion mechanism of mussels, the HA@TA-CS/SA scaffold of hydroxyapatite (HA) and chitosan (CS) is bridged by tannic acid (TA), which in turn binds sodium alginate (SA) using electrostatic interactions. The results showed that the HA@TA-CS/SA composite scaffold had better mechanical properties compared with recent literature data, reaching 68.09 MPa. It displayed excellent degradation and mineralization capabilities with strong biocompatibility . Furthermore, the antibacterial test results indicated that the curcumin-loaded scaffold inhibited and with 99.99% and 96.56% effectiveness, respectively. These findings show that 3D printed curcumin-loaded HA@TA-CS/SA scaffold has considerable promise for bone tissue engineering.

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