Development of Tannin-inspired Antimicrobial Bioadhesives

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2018 Mar 21

PMID 29555464

Citations 53

Authors

Jinshan Guo

Wei Sun

Jimin Peter Kim

Xili Lu

Qiyao Li

Min Lin

Oliver Mrowczynski

Elias B Rizk

Juange Cheng

Guoying Qian

Jian Yang

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: This manuscript describes the development of a new family of tannin-inspired antimicrobial bioadhesives derived from a facile, one-step Michael addition of tannic acid and gelatin under oxidizing conditions and crosslinked by silver nitrate. Our strategy is new and can be easily extended to other polymer systems, low-cost and readily scalable, and eliminate the concerns of potential neurological effect brought by mussel-inspired strategy due to the inclusion of dopamine. The tannin-inspired gelatin bioadhesives hold great promise for a number of applications in wound closure, tissue sealant, hemostasis, antimicrobial and cell/drug delivery, and would be interested to the readers from biomaterials, tissue engineering, and drug delivery area.

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