3D Printing of Bioceramics for Bone Tissue Engineering

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2019 Oct 18

PMID 31618857

Citations 23

Authors

Muhammad Jamshaid Zafar

Dongbin Zhu

Zhengyan Zhang

Affiliations

Soon will be listed here.

Abstract

Bioceramics have frequent use in functional restoration of hard tissues to improve human well-being. Additive manufacturing (AM) also known as 3D printing is an innovative material processing technique extensively applied to produce bioceramic parts or scaffolds in a layered perspicacious manner. Moreover, the applications of additive manufacturing in bioceramics have the capability to reliably fabricate the commercialized scaffolds tailored for practical clinical applications, and the potential to survive in the new era of effective hard tissue fabrication. The similarity of the materials with human bone histomorphometry makes them conducive to use in hard tissue engineering scheme. The key objective of this manuscript is to explore the applications of bioceramics-based AM in bone tissue engineering. Furthermore, the article comprehensively and categorically summarizes some novel bioceramics based AM techniques for the restoration of bones. At prior stages of this article, different ceramics processing AM techniques have been categorized, subsequently, processing of frequently used materials for bone implants and complexities associated with these materials have been elaborated. At the end, some novel applications of bioceramics in orthopedic implants and some future directions are also highlighted to explore it further. This review article will help the new researchers to understand the basic mechanism and current challenges in neophyte techniques and the applications of bioceramics in the orthopedic prosthesis.

Citing Articles

3D printed polycaprolactone/gelatin/ordered mesoporous calcium magnesium silicate nanocomposite scaffold for bone tissue regeneration.

Mirzavandi Z, Poursamar S, Amiri F, Bigham A, Rafienia M J Mater Sci Mater Med. 2024; 35(1):58.

PMID: 39348082 PMC: 11442632. DOI: 10.1007/s10856-024-06828-5.

Process Development for Fabricating 3D-Printed Polycaprolactone-Infiltrated Hydroxyapatite Bone Graft Granules: Effects of Infiltrated Solution Concentration and Agitating Liquid.

Thammarakcharoen F, Srion A, Suvannapruk W, Chokevivat W, Limtrakarn W, Suwanprateeb J Biomedicines. 2024; 12(9).

PMID: 39335674 PMC: 11429199. DOI: 10.3390/biomedicines12092161.

Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids.

Zhao X, Li N, Zhang Z, Hong J, Zhang X, Hao Y J Nanobiotechnology. 2024; 22(1):500.

PMID: 39169401 PMC: 11337604. DOI: 10.1186/s12951-024-02759-z.

Fatigue Performance of 3D-Printed Poly-Lactic-Acid Bone Scaffolds with Triply Periodic Minimal Surface and Voronoi Pore Structures.

Bakhtiari H, Nouri A, Tolouei-Rad M Polymers (Basel). 2024; 16(15).

PMID: 39125172 PMC: 11314528. DOI: 10.3390/polym16152145.

Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications.

Cinici B, Yaba S, Kurt M, Yalcin H, Duta L, Gunduz O Biomimetics (Basel). 2024; 9(7).

PMID: 39056850 PMC: 11275129. DOI: 10.3390/biomimetics9070409.

References

Brie J, Chartier T, Chaput C, Delage C, Pradeau B, Caire F . A new custom made bioceramic implant for the repair of large and complex craniofacial bone defects. J Craniomaxillofac Surg. 2012; 41(5):403-7. DOI: 10.1016/j.jcms.2012.11.005. View

Stevens A, Oliver C, Kirchmeyer M, Wu J, Chin L, Polsen E . Conformal Robotic Stereolithography. 3D Print Addit Manuf. 2018; 3(4):226-235. PMC: 5363219. DOI: 10.1089/3dp.2016.0042. View

Melchels F, Feijen J, Grijpma D . A review on stereolithography and its applications in biomedical engineering. Biomaterials. 2010; 31(24):6121-30. DOI: 10.1016/j.biomaterials.2010.04.050. View

Zerbo I, Bronckers A, de Lange G, van Beek G, Burger E . Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases. Clin Oral Implants Res. 2001; 12(4):379-84. DOI: 10.1034/j.1600-0501.2001.012004379.x. View

Liu H, Yazici H, Ergun C, Webster T, Bermek H . An in vitro evaluation of the Ca/P ratio for the cytocompatibility of nano-to-micron particulate calcium phosphates for bone regeneration. Acta Biomater. 2008; 4(5):1472-9. DOI: 10.1016/j.actbio.2008.02.025. View

He X, Fan X, Feng W, Chen Y, Guo T, Wang F . Incorporation of microfibrillated cellulose into collagen-hydroxyapatite scaffold for bone tissue engineering. Int J Biol Macromol. 2018; 115:385-392. DOI: 10.1016/j.ijbiomac.2018.04.085. View

Carfi Pavia F, Conoscenti G, Greco S, La Carrubba V, Ghersi G, Brucato V . Preparation, characterization and in vitro test of composites poly-lactic acid/hydroxyapatite scaffolds for bone tissue engineering. Int J Biol Macromol. 2018; 119:945-953. DOI: 10.1016/j.ijbiomac.2018.08.007. View

Wu C, Luo Y, Cuniberti G, Xiao Y, Gelinsky M . Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability. Acta Biomater. 2011; 7(6):2644-50. DOI: 10.1016/j.actbio.2011.03.009. View

Wang Y, Wang K, Li X, Wei Q, Chai W, Wang S . 3D fabrication and characterization of phosphoric acid scaffold with a HA/β-TCP weight ratio of 60:40 for bone tissue engineering applications. PLoS One. 2017; 12(4):e0174870. PMC: 5390984. DOI: 10.1371/journal.pone.0174870. View

10.

Xynos I, Edgar A, Buttery L, Hench L, Polak J . Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution. J Biomed Mater Res. 2001; 55(2):151-7. DOI: 10.1002/1097-4636(200105)55:2<151::aid-jbm1001>3.0.co;2-d. View

11.

Wagoner Johnson A, Herschler B . A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair. Acta Biomater. 2010; 7(1):16-30. DOI: 10.1016/j.actbio.2010.07.012. View

12.

Kolesky D, Homan K, Skylar-Scott M, Lewis J . Three-dimensional bioprinting of thick vascularized tissues. Proc Natl Acad Sci U S A. 2016; 113(12):3179-84. PMC: 4812707. DOI: 10.1073/pnas.1521342113. View

13.

Dimitriou R, Jones E, McGonagle D, Giannoudis P . Bone regeneration: current concepts and future directions. BMC Med. 2011; 9:66. PMC: 3123714. DOI: 10.1186/1741-7015-9-66. View

14.

Parent M, Baradari H, Champion E, Damia C, Viana-Trecant M . Design of calcium phosphate ceramics for drug delivery applications in bone diseases: A review of the parameters affecting the loading and release of the therapeutic substance. J Control Release. 2017; 252:1-17. DOI: 10.1016/j.jconrel.2017.02.012. View

15.

Zhu W, Qu X, Zhu J, Ma X, Patel S, Liu J . Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. Biomaterials. 2017; 124:106-115. PMC: 5330288. DOI: 10.1016/j.biomaterials.2017.01.042. View

16.

Littmann E, Autefage H, Solanki A, Kallepitis C, Jones J, Alini M . Cobalt-containing bioactive glasses reduce human mesenchymal stem cell chondrogenic differentiation despite HIF-1α stabilisation. J Eur Ceram Soc. 2018; 38(3):877-886. PMC: 5738970. DOI: 10.1016/j.jeurceramsoc.2017.08.001. View

17.

Tian Y, Lu T, He F, Xu Y, Shi H, Shi X . β-tricalcium phosphate composite ceramics with high compressive strength, enhanced osteogenesis and inhibited osteoclastic activities. Colloids Surf B Biointerfaces. 2018; 167:318-327. DOI: 10.1016/j.colsurfb.2018.04.028. View

18.

Butscher A, Bohner M, Doebelin N, Hofmann S, Muller R . New depowdering-friendly designs for three-dimensional printing of calcium phosphate bone substitutes. Acta Biomater. 2013; 9(11):9149-58. DOI: 10.1016/j.actbio.2013.07.019. View

19.

Westhauser F, Weis C, Prokscha M, Bittrich L, Li W, Xiao K . Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo. J Mater Sci Mater Med. 2016; 27(7):119. DOI: 10.1007/s10856-016-5732-3. View

20.

Bertassoni L, Cecconi M, Manoharan V, Nikkhah M, Hjortnaes J, Cristino A . Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Lab Chip. 2014; 14(13):2202-11. PMC: 4201051. DOI: 10.1039/c4lc00030g. View