Aligned Ice Templated Biomaterial Strategies for the Musculoskeletal System

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2023 Apr 14

PMID 37058583

Authors

Florencia Diaz

Nicholas Forsyth

Aldo R Boccaccini

Affiliations

Soon will be listed here.

Abstract

Aligned pore structures present many advantages when conceiving biomaterial strategies for treatment of musculoskeletal disorders. Aligned ice templating (AIT) is one of the many different techniques capable of producing anisotropic porous scaffolds; its high versatility allows for the formation of structures with tunable pore sizes, as well as the use of many different materials. AIT has been found to yield improved compressive properties for bone tissue engineering (BTE), as well as higher tensile strength and optimized cellular alignment and proliferation in tendon and muscle repair applications. This review evaluates the work that has been done in the last decade toward the production of aligned pore structures by AIT with an outlook on the musculoskeletal system. This work describes the fundamentals of the AIT technique and focuses on the research carried out to optimize the biomechanical properties of scaffolds by modifying the pore structure, categorizing by material type and application. Related topics including growth factor incorporation into AIT scaffolds, drug delivery applications, and studies about immune system response will be discussed.

Citing Articles

Aligned Ice Templated Biomaterial Strategies for the Musculoskeletal System.

Diaz F, Forsyth N, Boccaccini A Adv Healthc Mater. 2023; 12(21):e2203205.

PMID: 37058583 PMC: 11468517. DOI: 10.1002/adhm.202203205.

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