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Immunosuppressive Activity of Fusarium Toxins. Effects on Antibody Synthesis and Skin Grafts of Crude Extracts, T2-toxin and Diacetoxyscirpenol

Overview
Journal Immunology
Specialty Allergy & Immunology
Date 1979 Jan 1
PMID 369993
Citations 23
Authors
Y Rosenstein
C Lafarge-Frayssinet
G Lespinats
F LOISILLIER
P LAFONT
C Frayssinet
Affiliations
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Abstract

The inhibitory effect of crude Fusarium poae extracts, T2-toxin and diacetoxyscirpenol on synthesis of antibody to sheep red blood cells was investigated, as well as the effect of T2-toxin on skin graft rejection. Fusarium crude extracts, T2-toxin and diacetoxyscirpenol cause a significant reduction in thymus weight and inhibit responsiveness to sheep red blood cells. The effect on antibody synthesis was critically dependent on the drug doses used. The effect of an immunosuppressive dose of T2-toxin disappeared within 6 days after the end of the treatment. The administration of T2-toxin subsequent to immunization stops antibody synthesis. T2-toxin significantly prolongs the period required for skin graft rejection.

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References
1.
Liao L, Grollman A, Horwitz S . Mechanism of action of the 12,13-epoxytrichothecene, anguidine, an inhibitor of protein synthesis. Biochim Biophys Acta. 1976; 454(2):273-84. DOI: 10.1016/0005-2787(76)90230-6. View
2.
LAFONT P, Lafarge-Frayssinet C, Lafont J, Bertin G, Frayssinet France . [Toxic metabolites from Fusarium causing alimentary toxic aleukia (author's transl)]. Ann Microbiol (Paris). 1977; 128(2):215-20. View
3.
Ueno Y, Sato N, Ishii K, Sakai K, Enomoto M . Toxicological approaches to the metabolites of Fusaria. V. Neosolaniol, T-2 toxin and butenolide, toxic metabolites of Fusarium sporotrichioides NRRL 3510 and Fusarium poae 3287. Jpn J Exp Med. 1972; 42(5):461-72. View
4.
Hsu I, Smalley E, STRONG F, RIBELIN W . Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle. Appl Microbiol. 1972; 24(5):684-90. PMC: 380645. DOI: 10.1128/am.24.5.684-690.1972. View
5.
Sato N, Ueno Y, Enomoto M . Toxicological approaches to the toxic metabolites of Fusaria. VIII. Acute and subacute toxicities of T-2 toxin in cats. Jpn J Pharmacol. 1975; 25(3):263-70. DOI: 10.1254/jjp.25.263. View