Use of Cell Cultures for Predicting the Biological Effects of Mycotoxins

Overview

Journal Cell Biol Toxicol

Publisher Springer

Specialties Cell Biology
Toxicology

Date 1989 Jun 1

PMID 2766030

Citations 4

Authors

C Lafarge-Frayssinet

C Frayssinet

Affiliations

Soon will be listed here.

Abstract

The risk presented by mycotoxins is a toxicological problem. As the data given by physico-chemical analysis may be difficult to translate in terms of toxicity, however, especially when considering multiple contamination, we have developed a system for toxicological analysis of mycotoxins using cell cultures of different origins. The response of several cell types to a number of well defined mycotoxins was obtained in three days. This approach allowed us to: demonstrate and quantify a toxic effect, define some organ specificity related to the preferential action on a particular cell type, and detect an immunosuppressive effect. The results indicate that the system can be used for toxicological screening and that it has a predictive value for the pathological effects of tested products.

Citing Articles

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Cytotoxicity of mycotoxins evaluated by the MTT-cell culture assay.

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Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay.

Babich H, Borenfreund E Appl Environ Microbiol. 1991; 57(7):2101-3.

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In vitro effects of the nephrotoxins ochratoxin A and citrinin upon biochemical function of porcine kidney.

BRAUNBERG R, Gantt O, Barton C, Friedman L Arch Environ Contam Toxicol. 1992; 22(4):464-70.

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